28416-82-2

• 常用中文名：氟米松酸
• 常用英文名：Flumethasone Acid
• CAS号：28416-82-2
• 分子式：C₂₁H₂₆F₂O₅
• 分子量：396.425
• 发布时间：2018-07-13 13:18:36
• 更新时间：2026-07-01 20:37:25

名称

• 中文名: 6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-羧酸
• 英文名: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid
• 中文别名: 氟替卡松羧酸; 氟甲松酸; 丙酸氟替卡松杂质J; 6Α,9Α-二氟-11Β,17Α-二羟基-16Α-甲基-3-氧代雄甾-1,4-二烯-17Β-甲酸; 氟替卡松相关化合物J; 氟替卡松17-Β-羧酸; 氟替卡松中间体 FT1; 氟替卡松丙酸酯杂质9; 氟替卡松17Β羧酸; 氟替卡松17beta-羧酸Fluticasone 17beta-Cboxylic Acid; 氟美松酸; 氟米松酸(氟替卡松杂质); 6Α,9Α-二氟-17Α,11Β-二羟基-16Α-甲基-3-氧代雄甾-1,4-二烯-17Β-甲酸; 氟替卡松中间体 FT1 氟米松酸 氟替卡松羧酸; 丙酸氟替卡松杂质J1; (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11,17-二羟基-10,13,16-三甲基-3-氧亚基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊二烯并[A]菲-17-羧酸; 17Beta-羧酸氟替卡松; 丙酸氟替卡松杂质1; 氟替卡松杂质J; 氟米松酸: 6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-羧酸; 丙酸氟替卡松杂质6; 氟替卡松杂质11(氟替卡松RC J); 丙酸氟替卡松相关化合物J; 氟替卡松 17-BETA-羧酸
• 英文别名: Androsta-1,4-diene-17-cboxylic acid,6,9-difluoro-11,17- dihydroxy-16-Methyl-3-oxo-,(6|á,11|,16|á,17|á); 6A,9A-DIFLUORO-11SS,17A-DIHYDROXY-3-OXOANDROSTA-1,4-DIENE-17SS-CBOXYLIC ACID; (6A,11B,16A,17A)-6,9-DIFLUORO-11,17-diHYDROXY-16-METHY-OXOANDROSTA-1,4-DIENE-17-C; Fluticasone RC J; (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-cboxylic acid [Flumethasone Acid]; (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-Methyl-3-oxo-androsta-1,4-diene-17-cboxylic Acid; impurity J; (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-M; Androsta-1,4-diene-17-cboxylic acid,6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a); (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-DIFLUORO-11,17-DIHYDRO; (6a,11,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-cboxylic Acid; 6a,9a-Difluoro-11b,17a-dihydroxy-16a-methylpregna- 3-oxo-1,4-diene-17b-cboxylic Acid; Fluticasone IMpurity J; 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-cboxylic Acid Discontinued see F599490; (6S,8S,9R,10S,11S,13S,14S,16R,17R); ANDROSTA-1,4-DIENE-17-CBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6ALPHA,11BETA,16ALPHA,17ALPHA); Fluticasone 17β-Cboxylic Acid; Fluticasone 17-Cboxylic Acid; 6a,9a-Difluoro-11,17a-dihydroxy-16a-methylpregna-3-oxo-1,4-diene-17-cboxylic Acid; 1,4-diene-17-cboxylic acid; (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-ox; flumethason acid; FLUMETHASONE ACID /CAS NO.:28-2; (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-cboxylic acid; Fluticasone propionate Intermediates (Flumethasone acid); 6α,9α-Difluoro-11β,17α-dihydroxy-16α-Methylpregna- 3-oxo-1,4-diene-17β-cboxylic Acid; Fluticasone Related Compound J; 6a,9a-difluoro-11 P,17a-dihydroxy-16a-methyl-3- oxoandrosta-1,4-diene-17P-cboxylic acid; BNKY011-FP01; 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-cboxylic Acid Discontinued see product # F599490; Fluticasone Propionate Related Compound J; Fluticasone Cboxylic Acid; 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-cboxylic acid; ANDROSTA-1,4-DIENE-17-CBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6A,11SS,16A,17A); Androsta-1,4-diene-17-cboxylic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α); (6a,11b,16a,17a)-6; (6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-cboxylic acid; (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-cboxyl; 6α,9-Difluoro-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-cboxylic acid; Fluticasone Propionate Related Compound J (6alpha, 9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha; Propionate Impurity J; 17-cboxylic acid; 6a,9a-Difluoro-1117a-dihydroxy-3-oxoandrosta-1,4-diene-17cboxylic Acid Discontinued see product # F599490; flumethasone acid; FluMethasone acid; Fluticasone Propionate Impurity 1; (6S,8S,9R,10S,11S,13R,14S,17S)-17-acetyl-6,9-difluoro-11-hydroxy-10,13-dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanth ren-3-one; ANDROSTA-1,4-DIENE-17-CBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6α,11β,16α,17α); (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-cboxylic acid; (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid; Fluticasone Impurity 11(Fluticasone RC J); Fluticasone 17-beta-Cboxylic Acid; (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid; Axon; 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17-cboxylic Acid Discontinued see product # F599490; Flumetasone acid; (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-cboxylic; Fluticasone Acid; (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-cboxylic acid; BNKY012-FF01; Fluticasone 17b-Cboxylic Acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 568.4±50.0 °C at 760 mmHg
• 熔点: 303-305ºC
• 分子式: C₂₁H₂₆F₂O₅
• 分子量: 396.425
• 闪点: 297.6±30.1 °C
• 精确质量: 396.174835
• PSA: 94.83000
• LogP: 0.81
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.585
• 储存条件: 室温，干燥，密封

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P301 + P312 + P330-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 危险品运输编码: UN 3077 9 / PGIII

合成路线

2135-17-3 ~98% 28416-82-2

文献：US2010/99654 A1, ; Page/Page column 5 ;

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