111-46-6

• 常用中文名：二乙二醇
• 常用英文名：Diethylene glycol
• CAS号：111-46-6
• 分子式：C₄H₁₀O₃
• 分子量：106.120
• 相关类别： 有机原料 醇、酚、酚醇类化合物及衍生物 无环醇
• 发布时间：2018-02-04 08:00:00
• 更新时间：2024-01-02 19:11:22
• Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. DEG is a widely used solvent.
• 用作气体脱水剂和芳烃抽提溶剂，也用作纺织品的润滑剂、软化剂和整理剂，以及增塑剂、增湿剂、上浆剂、硝基纤维素、树脂和油脂等溶剂。

名称

• 中文名: 二乙二醇
• 英文名: Diethylene glycol
• 中文别名: 2,2'-氧代二乙醇; 二(羟乙基)醚; 二甘醇
• 英文别名: Q2O2Q; 2,2'-Oxydiethanol; Ethanol, 2,2'-oxydi-; Bis(2-hydroxyethyl)ether; ether, bis(2-hydroxyethyl); DEG; EINECS 203-872-2; Ethanol, 2,2'-oxybis-; Ethylene diglycol; 2,2'-dihydroxydiethyl ether; 2,2'-Oxybis[Ethanol]; bis(2-hydroxyethyl) ether; diethyleneglycol; MFCD00002882

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 245.7±0.0 °C at 760 mmHg
• 熔点: −10 °C(lit.)
• 分子式: C₄H₁₀O₃
• 分子量: 106.120
• 闪点: 143.3±0.0 °C
• 精确质量: 106.062996
• PSA: 49.69000
• LogP: -1.51
• 外观性状: 透明液体
• 蒸汽密度: 2.14 (vs air)
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.442
• 储存条件:

  1.密封于阴凉、干燥处保存。确保工作间有良好的通风设施。

  2.远离火源、水源。储存的地方远离氧化剂。

• 稳定性: 1.避免与氧化物、潮湿的水分接触。 2.无色、无臭、透明，具有吸湿性的粘稠液体。有辛辣的甜味。 与溶解性能与乙二醇相似，但对烃类的溶解能力较强。二甘醇能与水、乙醇、乙二醇、丙酮、氯仿、糠醛等混溶。与乙醚、四氯化碳、二硫化碳、直链脂肪烃、芳香烃等不混溶。松香、虫胶、醋酸纤维素和大多数油脂不溶于二甘醇，但能溶解硝酸纤维素、醇酸树脂、聚酯树脂、聚氨基甲酸乙酯和大多数染料。易燃，低毒。具有醇、醚的一般化学性质。 3. 存在于烟叶、烟气中。 4. 食入后的症状类似于乙二醇，请参阅乙二醇。用作 酏剂产生致命的毒害作用。
• 水溶解性: SOLUBLE
• 凝固点: -10.45℃
• 分子结构:

  1、 摩尔折射率：25.39

  2、 摩尔体积（cm³/mol）：95.9

  3、 等张比容（90.2K）：244.4

  4、 表面张力（dyne/cm）：42.1

  5、 极化率（10^-24cm³）：10.06

• 计算化学:

  1.疏水参数计算参考值（XlogP）:-1.3

  2.氢键供体数量:2

  3.氢键受体数量:3

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积49.7

  7.重原子数量:7

  8.表面电荷:0

  9.复杂度:26.1

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色、无臭、透明，具有吸湿性的黏稠液体，有辛辣气味，无腐蚀性。

  2. 沸点（ºC,101.3kPa）：245

  3. 熔点（ºC）：-10.5

  4. 相对密度（g/mL,20/4ºC）：1.118

  5. 相对蒸汽密度（g/mL,空气=1）：2.14

  6. 折射率（15ºC）：1.4490

  7. 折射率（20ºC）：1.4472

  8. 常温折射率（n²⁵）：1.446

  9. 黏度（mPa·s,20ºC）：35.7

  10. 黏度（mPa·s,25ºC）：30

  11. 闪点（ºC,闭口）：143

  12. 燃点（ºC）：229

  13. 蒸发热（KJ/mol,b.p.）：52.297

  14. 燃烧热（KJ/mol）：2380.2

  15. 比热容（KJ/(kg·K),20ºC,定压）：2.31

  16. 电导率（S/m,20ºC）：5.86×10^-7

  17. 蒸气压（kPa,20ºC）：<0.0013

  18. 体膨胀系数（K^-1,20ºC）：0.000635

  19. 爆炸下限（%,V/V）：0.7

  20. 爆炸上限（%,V/V）：22

  21. 溶解性：能与水、乙醇、乙二醇、丙酮、氯仿、糠醛等混溶。与乙醚、四氯化碳、二硫化碳、直链脂肪烃、芳香烃等不混溶。

  22. 相对密度（25℃，4℃）：1.1122

  23. 临界温度（ºC）：476.85

  24. 临界压力（MPa）：4.7

  25. 溶度参数(J·cm^-3)^0.5：27.775

  26. van der Waals面积（cm²·mol^-1）：8.920×10⁹

  27. van der Waals体积（cm³·mol^-1）：60.700

  28. 气相标准燃烧热(焓)(kJ·mol^-1)：-2432.0

  29. 气相标准声称热(焓)( kJ·mol^-1) ：-571.2

  30. 液相标准燃烧热(焓)(kJ·mol^-1)：-2374.7

  31. 液相标准声称热(焓)( kJ·mol^-1)：-628.5

  32. 液相标准热熔(J·mol^-1·K^-1) ：258.4

MSDS

第一部分：化学品名称 化学品中文名称: 二乙二醇；二甘醇 化学品英文名称: Diethylene glycol；Diglycol CAS No.: 111-46-6 分子式: C4H10O3 分子量: 106.12 第二部分：成分/组成信息 化学品名称：二乙二醇；二甘醇 第三部分：危险性概述 侵入途径: 吸入 食入 经皮吸收 健康危害: 未见本品引起职业中毒的报道。口服引起恶心、呕吐、腹痛、腹泻及肝、肾损害。可因严重肾损害而致死。 燃爆危险: 本品可燃。 第四部分：急救措施 皮肤接触: 脱去污染的衣着，用大量流动清水彻底冲洗。 眼睛接触: 立即翻开上下眼睑，用流动清水或生理盐水冲洗。 吸入: 脱离现场至空气新鲜处。就医。 食入: 给饮足量温水，催吐，就医。 第五部分：消防措施 危险特性: 遇高热、明火或与氧化剂接触，有引起燃烧的危险。 有害燃烧产物: 一氧化碳、二氧化碳。 灭火方法及灭火剂: 尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。用水喷射逸出液体，使其稀释成不燃性混合物，并用雾状水保护消防人员。灭火剂：水、雾状水、抗溶性泡沫、干粉、二氧化碳、砂土。 闪点(℃): 124 自燃温度(℃): 引燃温度(℃)：228 爆炸下限[%(V/V)]: 无资料 爆炸上限[%(V/V)]: 无资料 第六部分：泄漏应急处理 应急处理: 迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自吸过滤式防毒面具（全面罩），穿防毒服。尽可能切断泄漏源。防止流入下水道、排洪沟等限制性空间。小量泄漏：用砂土、蛭石或其它惰性材料吸收。也可以用大量水冲洗，洗水稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。 第七部分：操作处置与储存 操作注意事项: 密闭操作，注意通风。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防毒物渗透工作服，戴防化学品手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、酸类接触。搬运时轻装轻卸，防止包装破损。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。 储存注意事项: 储存于阴凉、通风的库房。远离火种、热源。应与氧化剂、酸类分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。 第八部分：接触控制/个体防护 最高容许浓度: 中 国 MAC：未制订标准前苏联MAC：10mg／m3 美国TLV—TWA：未制订标准 工程控制: 密闭操作，注意通风。 呼吸系统防护: 空气中浓度超标时，应该佩戴防毒面具。 眼睛防护: 必要时戴安全防护眼镜。 身体防护: 穿工作服。 手防护: 戴防化学品手套。 其他防护: 工作现场严禁吸烟。避免长期反复接触。定期体检。保持良好的卫生习惯。 第九部分：理化特性 外观与性状: 无色、无臭、开始味甜回味苦的粘稠液体，具有吸湿性。 熔点(℃): -8．0 沸点(℃): 245．8 相对密度(水=1): 1．12(20℃) 相对蒸气密度(空气=1): 3．66 饱和蒸气压(kPa): 0．13(91．8℃) 闪点(℃): 124 引燃温度(℃): 引燃温度(℃)：228 爆炸上限%(V/V): 无资料 爆炸下限%(V/V): 无资料 分子式: C4H10O3 分子量: 106.12 溶解性: 与水混溶，不溶于苯、甲苯、四氯化碳。 主要用途: 用作人造丝的软化剂和烟草的湿润剂，还是某些化工产品的中间体，也用作汽车发动机防冻剂、刹车油等。 第十部分：稳定性和反应活性 稳定性: 在常温常压下 稳定 禁配物: 强氧化剂、强酸。 聚合危害: 不能出现 分解产物: 一氧化碳、二氧化碳。 第十一部分：毒理学资料 急性毒性: LD50：16600mg／kg(大鼠经口)；26500mg／kg(小鼠经口) LC50： 第十三部分：废弃处置 废弃处置方法: 处置前应参阅国家和地方有关法规。建议用焚烧法处置。 第十四部分：运输信息 运输注意事项: 运输前应先检查包装容器是否完整、密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与氧化剂、酸类等混装混运。船运时，应与机舱、电源、火源等部位隔离。公路运输时要按规定路线行驶。 第十六部分：其他信息 参考文献: 1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989 填表时间: 年月日 其他信息: 3 MSDS修改日期: 年月日

毒性和生态

毒理学数据: 1、刺激性：兔子经皮：500mg 轻度刺激。 兔子经眼：50mg 轻度刺激。 2、急性毒性：大鼠经口LD50：12565mg/kg；兔子经皮LD50：11890mg/kg 3、属微毒类。可经皮吸收，对皮肤黏膜刺激小。与乙二醇相似对中枢神经系统有抑制作用。能引起肾脏病理改变及尿路结石。人一次口服致死量估计为1mL/kg。服用二甘醇后约24小时出现恶心、呕吐、腹痛、腹泻等肠胃道症状。致死者随之出现头痛、肾区疼痛、一时性多尿然后少尿、嗜睡、面部轻度浮肿等。无尿发生后2～7日内昏迷而死。故本品应禁作药用，避免长期与皮肤接触。 生态学数据: 对水体有轻微的危害。 CHEMICAL IDENTIFICATION RTECS NUMBER : ID5950000 CHEMICAL NAME : Diethylene glycol CAS REGISTRY NUMBER : 111-46-6 BEILSTEIN REFERENCE NO. : 0969209 LAST UPDATED : 199712 DATA ITEMS CITED : 56 MOLECULAR FORMULA : C4-H10-O3 MOLECULAR WEIGHT : 106.14 WISWESSER LINE NOTATION : Q2O2Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Human REFERENCE : 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,731,1969 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 2400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Liver - other changes Nutritional and Gross Metabolic - metabolic acidosis REFERENCE : JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 109,731,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12565 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3836,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3836,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6565 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7826 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15650 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23700 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - muscle weakness Liver - other changes REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,142,1945 TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 130 mg/m3/2H TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9719 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in spleen REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 6,342,1947 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 13300 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 9 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,101,1939 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 3300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 4400 mg/kg TOXIC EFFECTS : Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 11890 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2236 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 4472 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2688 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 7800 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - muscle weakness Liver - other changes REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,142,1945 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 14 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 297 gm/kg/99D-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Related to Chronic Data - death REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,261,1986 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/m3/2H/26W-I TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - emphysema Related to Chronic Data - death REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/m3/11W-I TOXIC EFFECTS : Cardiac - other changes Liver - fatty liver degeneration Related to Chronic Data - death REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 105 gm/kg/18D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,261,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 17300 uL/kg/30D-I TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 29,325,1947 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 890 gm/kg/53W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder - changes in both tubules and glomeruli REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 28,40,1946 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2500 mg/kg/82W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Blood - tumors REFERENCE : VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 420 mg/kg/22W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Blood - tumors REFERENCE : VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 mg/m3/2H/30W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Skin and Appendages - tumors REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(2),36,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1250 mg/kg/66W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Blood - tumors REFERENCE : VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1752 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 36,55,1967 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 584 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,149,1945 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 840 mg/kg/81W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Blood - tumors REFERENCE : VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 50 gm/kg SEX/DURATION : female 1-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 27,801,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 76420 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0291-1175 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 38212 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0291-1175 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 343 gm/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Newborn - sex ratio REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,622,1990 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 343 gm/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - other postnatal measures or effects REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,622,1990 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 50 gm/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-159327 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 100 gm/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-159327 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 23 ppm (100 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 25544 No. of Facilities: 27975 (estimated) No. of Industries: 222 No. of Occupations: 129 No. of Employees: 273598 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 25544 No. of Facilities: 55518 (estimated) No. of Industries: 292 No. of Occupations: 178 No. of Employees: 890145 (estimated) No. of Female Employees: 261558 (estimated)

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H302-H373
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S46
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 1
• RTECS号: ID5950000
• 海关编码: 2909410000

合成路线

上下游产品

上游产品  9
75-21-8 96-49-1 67-56-1 10143-54-1
22397-31-5 62698-60-6 107-21-1 124-38-9
106-93-4
下游产品  10
105589-77-3 105649-50-1 106-78-5 106-12-7
110-09-8 107-79-9 4408-82-6 4074-88-8
371-62-0 34604-52-9

制备

1.一缩二乙二醇是环氧乙烷制乙醇时的副产品。 工艺流程： 用直接水合法 将环氧乙烷与水按1：8混合送入混合反应器，在150℃MPa下，反应40-60min,生成脱水塔进一步脱水；塔底的乙二醇混合液送入乙二醇塔，塔顶可得99.8%以上的乙二醇。塔底液送入一缩精馏塔，在塔顶温度135-140℃,压力4.0KPa下，从塔顶得到一缩二乙二醇。继续分离，可得二缩三乙二醇、三缩四乙二醇。 精制方法：所含杂质有水、乙二醇、三甘醇等。可用减压蒸馏后分步结晶的方法精制。取二甘醇1650mL进行减压分馏，弃去480mL初馏分，收集1000mL中间馏分进行分步结晶，可得700mL二甘醇。 2. 与酸酐作用时生成酯，与烷基硫酸酯或卤代烃作用生成醚。 3. 合成：由环氧乙烷与乙二醇作用而制得。也是环氧乙烷水合制乙二醇时的副产品。

海关

海关编码	2909410000
中文概述	2909410000 2,2'-氧联二乙醇(二甘醇)。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2909410000 2,2'-oxydiethanol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%