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57248-88-1

57248-88-1 structure
57248-88-1 structure
  • Name: Pamidronate disodium
  • Chemical Name: Disodium Pamidronate Hydrate
  • CAS Number: 57248-88-1
  • Molecular Formula: C3H11NNa2O7P2
  • Molecular Weight: 281.05
  • Catalog: API Water, electrolyte and acid-base balance regulator Electrolyte balance regulator
  • Create Date: 2018-02-24 08:00:00
  • Modify Date: 2024-01-02 18:32:27
  • Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone.
Name Disodium Pamidronate Hydrate
Synonyms Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]
Pamidronate disodium salt
Pamidronate disodium
Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)]
APD
Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate
MFCD01938386
EINECS 260-647-1
(3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium
Pamidronate (Disodium)
Description Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone.
Related Catalog
References

[1]. Zarychanski, R., et al., Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol, 2006. 81(1): p. 73-5.
Melting Point 300 °C
Molecular Formula C3H11NNa2O7P2
Molecular Weight 281.05
PSA 186.59000
Appearance solid | white
Storage condition 2-8°C
Water Solubility H2O: 28 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ6525000
CHEMICAL NAME :
Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt
CAS REGISTRY NUMBER :
57248-88-1
LAST UPDATED :
199709
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C3-H9-N-O7-P2.2Na
MOLECULAR WEIGHT :
279.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
750 ug/kg/5D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,320,1994
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
600 ug/kg/6H-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,622,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
900 ug/kg
TOXIC EFFECTS :
Musculoskeletal - joints
REFERENCE :
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 31,499,1997 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1740 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
60 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992
HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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