6160-12-9

• 常用中文名：五水合硫酸司巴丁
• 常用英文名：(-)-Sparteine sulfate pentahydrate
• CAS号：6160-12-9
• 分子式：C₁₅H₂₆N_2.H₂SO_4.5H₂O
• 分子量：422.54
• 相关类别： 化学试剂 有机试剂 磺酸盐/亚磺酸盐
• 发布时间：2018-08-12 12:10:30
• 更新时间：2024-01-06 13:57:56
• (-)-Sparteine硫酸盐五水合物是1a类抗心律失常药;也是钠通道抑制剂, 是一种生物碱, 可螯合二价钙和镁。

名称

• 中文名: 五水合硫酸司巴丁
• 英文名: (-)-Sparteine sulfate pentahydrate
• 中文别名: 五水合硫酸金雀花碱; 鹰爪豆碱; 硫酸金雀花碱; 硫酸金雀花碱; 五水合硫酸金雀花
• 英文别名: Synastrin; MFCD00149333; Spartein-Asal; Sparteine sulfate hydrate (1:1:5); SPARTEINE SULFATE,CRYSTALLIZED; EINECS 206-078-4; [7S-(7a,7aa,14a,14ab)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine Sulfate Penyahydrate; l-Sparteine Sulfate Pentahydrate; (-)-Sparteine pentahydrate sulfate; Lupinidine sulfate pentahydrate; Sparteine sulfate pentahydrate; Spartocin; Actospar; LUPINIDINE; Depasan; (-)-Sparteinesulfatepentahydrate; 7,14-Methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-, sulfate, hydrate (1:1:5); SparteiniSulfas; (-)-Sparteine (sulfate pentahydrate)

物化性质

• 沸点: 340.9ºC at 760 mmHg
• 熔点: 134-141ºC
• 分子式: C₁₅H₂₆N_2.H₂SO_4.5H₂O
• 分子量: 422.54
• 闪点: 148.3ºC
• PSA: 135.61000
• LogP: 2.32740
• 外观性状: 白色细结晶粉末
• 储存条件:

  2-8℃ 避光，阴凉干燥处，密封保存

• 稳定性:

  常温常压下稳定

• 分子结构:

  1、 摩尔折射率：71.00

  2、 摩尔体积（m³/mol）：216.3

  3、 等张比容（90.2K）：557.3

  4、 表面张力（dyne/cm）：44.0

  5、 极化率（10 ^-24cm ³）：28.14

• 计算化学:

  1、 氢键供体数量：7

  2、 氢键受体数量：11

  3、 可旋转化学键数量：0

  4、 拓扑分子极性表面积（TPSA）：86.1

  5、 重原子数量：27

  6、 表面电荷：0

  7、 复杂度：344

  8、 同位素原子数量：0

  9、 确定原子立构中心数量： 4

  10、 不确定原子立构中心数量：0

  11、 确定化学键立构中心数量：0

  12、 不确定化学键立构中心数量：0

  13、 共价键单元数量：7

• 更多:

  1. 性状：未确定

  2. 密度（g/mL, 25 ℃ ）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：133-140

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，2.67KPa）：未确定

  7. 折射率：未确定

  8. 闪点（º F）：未确定

  9. 比旋光度（º, C=2, 水）：-28

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于水， 0.1g /mL

生物活性

• 描述: (-)-Sparteine硫酸盐五水合物是1a类抗心律失常药;也是钠通道抑制剂, 是一种生物碱, 可螯合二价钙和镁。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 心血管疾病

MSDS

Name: (-)-Sparteine Sulfate Pentahydrate 99% Material Safety Data Sheet Synonym: Lupinidine CAS: 6160-12-9 Section 1 - Chemical Product MSDS Name:(-)-Sparteine Sulfate Pentahydrate 99% Material Safety Data Sheet Synonym:Lupinidine Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 6160-12-9 (-)-Sparteine Sulfate Pentahydrate 99% unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 6160-12-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 133.00 - 140.00 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C15H26N2.H2SO4.5H2O Molecular Weight: 422.53 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 6160-12-9 unlisted. LD50/LC50: Not available. Carcinogenicity: (-)-Sparteine Sulfate Pentahydrate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 6160-12-9: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 6160-12-9 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 6160-12-9 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 对水少是稍微危害的，不要让未稀释或大量的产品接触地下水、水道或污水系统 若无政府许可，勿将材料排入周围环境.

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S24/25
• WGK德国: 3
• RTECS号: WG6430000