93107-30-3

• 常用中文名：1-环丙基-6,7-二氟-1,4-二氢-4-氧代-3-喹啉甲酸
• 常用英文名：1-CYCLOPROPYL-6,7-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
• CAS号：93107-30-3
• 分子式：C₁₃H₉F₂NO₃
• 分子量：265.212
• 发布时间：2018-12-16 02:14:07
• 更新时间：2024-01-04 14:33:52

名称

• 中文名: 1-环丙基-6,7-二氟-1,4-二氢-4-氧喹啉-3-羧酸
• 英文名: 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid
• 中文别名: 1-环丙基-6,7-二氟-1,4-二氢-4-氧代-3-喹啉甲酸; 1-环丙基-6,7-二氟-1,4-二氢-4-氧代喹啉-3-甲酸; 盐酸贝西沙星中间体
• 英文别名: 1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-; 1-Cyclopropyl-6-, 7-Difluoro-1,4-Dihydro-4-Oxoquinoline-3-carboxylic Acid

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 434.2±45.0 °C at 760 mmHg
• 熔点: 289 °C
• 分子式: C₁₃H₉F₂NO₃
• 分子量: 265.212
• 闪点: 216.4±28.7 °C
• 精确质量: 265.055054
• PSA: 59.30000
• LogP: 1.41
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.655
• 储存条件: 室温，干燥

MSDS

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline- Revision number: 5 3-carboxylic Acid SAFETY DATA SHEET Section1. IDENTIFICATION Product name:1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDSNot classified HEALTH HAZARDS Reproductive toxicityCategory 2 ENVIRONMENTAL HAZARDS Acute aquatic hazardCategory 3 Long-term aquatic hazardCategory 3 GHS label elements, including precautionary statements Pictograms or hazard symbols Signal wordWarning Suspected of damaging fertility or the unborn child Hazard statements Harmful to aquatic life Harmful to aquatic life with long lasting effects Precautionary statements: Obtain special instructions before use. [Prevention] Do not handle until all safety precautions have been read and understood. Avoid release to the environment. Use personal protective equipment as required. [Response]IF exposed or concerned: Get medical advice/attention. [Storage]Store locked up. [Disposal]Dispose of contents/container through a waste management company authorized by the local government. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture:Substance 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid Components: Percent:>98.0%(LC)(T) 93107-30-3 CAS Number: Chemical Formula:C13H9F2NO3 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic Acid Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention. Skin contact:Remove/Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. Get medical advice/attention. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Get medical advice/attention. Ingestion:Get medical advice/attention.Rinse mouth. Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air- tight goggles. Section5. FIRE-FIGHTING MEASURES Suitable extinguishingDry chemical, foam, water spray, carbon dioxide. media: Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to from the chemical:generate poisonous fume. Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep Personal precautions, protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should emergency procedures: be controlled around the leakage area by roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations. Section7. HANDLING AND STORAGE Precautions for safe handling Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a closed system if possible. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling: Avoid all contact! Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a cool and dark place. Store locked up. Store away from incompatible materials such as oxidizing agents. Packaging material:Comply with laws. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator, etc. Use respirators approved under appropriate government standards and follow local and national regulations. Hand protection:Impervious gloves. Safety goggles. A face-shield, if the situation requires. Eye protection: Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires. 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic Acid Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Solid Form:Crystal- Powder White - Almost white Colour: Odour:No data available pH: No data available Melting point/freezing point:289°C No data available Boiling point/range: Flash point:No data available Flammability or explosive limits: No data available Lower: Upper:No data available Relative density:No data available Solubility(ies): No data available [Water] [Other solvents] Hot dimethylformamide(DMF) Soluble: Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen fluoride products: Section11. TOXICOLOGICAL INFORMATION No data available Acute Toxicity: Skin corrosion/irritation: No data available No data available Serious eye damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: No data available IARC = NTP =No data available No data available Reproductive toxicity: Section12. ECOLOGICAL INFORMATION Ecotoxicity: Fish:No data available Crustacea:No data available Algae:No data available Persistence / degradability: No data available BioaccumulativeNo data available potential(BCF): Mobility in soil Log Pow:No data available Soil adsorption (Koc):No data available Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic Acid Section14. TRANSPORT INFORMATION Hazards Class:Does not correspond to the classification standard of the United Nations UN-No:Not listed Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 62-52/53
• 安全声明 (欧洲): 22-36/37-61
• 海关编码: 2933499090

合成路线

98349-25-8 ~98% 93107-30-3

文献：Grohe, Klaus; Heitzer, Helmut Liebigs Annalen der Chemie, 1987 , p. 29 - 37

82419-36-1 ~% 93107-30-3

文献：US5703231 A1, ;

127371-54-4 ~85% 93107-30-3

文献：Hong, Wan Pyo; Lee, Kee-Jung Synthesis, 2006 , # 6 p. 963 - 968

101799-76-2 ~% 93107-30-3

文献：Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991

110600-97-0 ~% 93107-30-3

文献：Journal of Heterocyclic Chemistry, , vol. 24, # 1 p. 181 - 185

88419-56-1 ~% 93107-30-3

文献：Liebigs Annalen der Chemie, , p. 29 - 37

98349-24-7 ~% 93107-30-3

文献：Liebigs Annalen der Chemie, , p. 29 - 37

101799-75-1 ~% 93107-30-3

文献：Liebigs Annalen der Chemie, , p. 29 - 37

104600-15-9 ~% 93107-30-3

文献：Liebigs Annalen der Chemie, , p. 29 - 37

上下游产品

上游产品  7
98349-25-8 82419-36-1 101799-76-2 110600-97-0
88419-56-1 98349-24-7 104600-15-9
下游产品  8
108461-04-7 108461-05-8 93107-08-5 93107-32-5
85721-33-1 112398-08-0 103237-52-1 93107-34-7

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%