112398-08-0

• 常用中文名：达诺沙星
• 常用英文名：Danofloxacine
• CAS号：112398-08-0
• 分子式：C₁₉H₂₀FN₃O₃
• 分子量：357.379
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-07-23 16:55:08
• 更新时间：2026-07-01 14:00:34
• Danofloxacin 是一种具有口服活性第的三代氟喹诺酮抗菌剂,对大多数革兰氏阴性和革兰氏阳性细菌,支原体和衣原体物种具有广谱的活性,并通过抑制细菌的 DNA 回转酶发挥抗菌作用。Danofloxacinh 可用于牛,猪和鸡呼吸道疾病的研究。

名称

• 中文名: 达氟沙星
• 英文名: Danofloxacin
• 中文别名: 达氟沙星溶液,100PPM; 1-环丙基-6-氟-7-((1S,4S)-5-甲基-2,5-二氮杂二环[2.2.1]庚烷-2-基)-4-氧代-1,4-二氢喹啉-3-羧酸; 达氟沙星(丹诺沙星,单诺沙星); 甲醇中达氟沙星; 达氟沙星溶液, 1000PPM; 甲醇中达诺沙星; 丹诺沙星; 达诺沙星Danofloxacin; 甲醇中达氟沙星(丹诺沙星); 达氟沙星溶液, 1000UG/ML 甲醇溶液, 100PPM; 达氟沙星 标准品; 单诺沙星; 蜂蜜中达氟沙星; 甲醇中达氟沙星溶液; 丹诺沙星/达氟沙星/达诺沙星; 达氟沙星检测标准品; 水中达氟沙星/介质:0.03MOL/L氢氧化钠; 达氟沙星溶液, 100UG/ML 甲醇溶液, 100PPM
• 英文别名: Danofloxacin, Vetranal; 1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; DANOFLOXACIN; DANOFLOXACIN //BP; Danofloxacin 100 μg/mL in Acetonitrile; danofloxacin; Danofloxacino; Dafloxacin; 1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Danofloxacin free base; 3-Quinolinecboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]ht-2-yl]-4-oxo; (1S)-1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinolinecarboxylic acid; ADVOCIN(R); DANOFLOXACIN BASE; Danofloxacin solution,1000ppm; 1-cyclopropyl-6-fluoro-7-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]htan-2-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; DanofloxacinQ: What is Danofloxacin Q: What is the CAS Number of Danofloxacin Q: What is the storage condition of Danofloxacin; Chlorotoluron Impurity 12 Hydrochloride (Chlordimeform Hydrochloride); 1-Cyclopropyl-6-Fluoro-7-[(1S,4S)-3-Methyl-3,6-Diazabicyclo[2.2.1]Htan-6-Yl]-4-Oxo-Quinoline-3-Cboxylic Acid; Inhibitor,Antibiotic,DNA-gyrase,respiratory,mycoplasma,inhibit,Fluoroquinolone,Danofloxacin,am-positive,DNA/RNA Synthesis,orally,chlamydia,bacteria,am-negative,Bacterial,antimicrobial; Danofloxacin,Advocin; Danofloxacin Solution, 100ppm; Danofloxacininmethanol; advocin

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 569.3±50.0 °C at 760 mmHg
• 熔点: 268-272ºC
• 分子式: C₁₉H₂₀FN₃O₃
• 分子量: 357.379
• 闪点: 298.1±30.1 °C
• 精确质量: 357.148865
• PSA: 65.78000
• LogP: 1.20
• 外观性状: 无色粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.679
• 储存条件: 2-8℃，充氩保存
• 水溶解性: Soluble in water, acetic acid and DMSO

生物活性

• 描述: Danofloxacin 是一种具有口服活性第的三代氟喹诺酮抗菌剂,对大多数革兰氏阴性和革兰氏阳性细菌,支原体和衣原体物种具有广谱的活性,并通过抑制细菌的 DNA 回转酶发挥抗菌作用。Danofloxacinh 可用于牛,猪和鸡呼吸道疾病的研究。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Erjie Tian, et al. Population Pharmacokinetics for Danofloxacin in the Intestinal Contents of Healthy and Infected Chickens. J Vet Pharmacol Ther. 2019 Sep;42(5):556-563.

  [2]. Xia Xiao, et al. Comparative Pharmacokinetics of Danofloxacin in Healthy and Pasteurella Multocida Infected Ducks. J Vet Pharmacol Ther. 2018 Dec;41(6):912-918.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn,Xi
• 风险声明 (欧洲): 20/21/22-36/37/38
• 安全声明 (欧洲): 22-24/25
• 危险品运输编码: NONH for all modes of transport

合成路线

93107-30-3 52321-26-3 ~78% 112398-08-0

文献：McGuirk; Jefson; Mann; Elliott; Chang; Cisek; Cornell; Gootz; Haskell; Hindahl; LaFleur; Rosenfeld; Shryock; Silvia; Weber Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 611 - 620

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