59652-29-8

• 常用中文名：丁呋洛尔盐酸盐
• 常用英文名：Bufuralol
• CAS号：59652-29-8
• 分子式：C₁₆H₂₄ClNO₂
• 分子量：297.82000
• 发布时间：2018-05-01 08:00:00
• 更新时间：2024-01-06 13:15:16
• Bufuralol, also known as Ro-34787, is a β-adrenoceptor antagonist with partial agonist activity and is potentially useful for the treatment of hypertension. It is metabolized by CYP2D6. Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor.

名称

• 中文名: 丁呋洛尔盐酸盐
• 英文名: (+/-)-bufuralol hydrochloride
• 中文别名: 盐酸丁呋洛尔
• 英文别名: a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol; Bufuralol HCl; AngiumHCl; 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-ethanohydrochloride; 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)ethanolhydrochloride; BUFURALOL,HYDROCHLORIDE; bufurololhydrochloride; ANGIUM; ro3-4787

物化性质

• 熔点: 143-146ºC
• 分子式: C₁₆H₂₄ClNO₂
• 分子量: 297.82000
• 精确质量: 297.15000
• PSA: 45.40000
• LogP: 4.60960
• 储存条件: 库房通风低温干燥,与食品原料类分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KK0207500 CHEMICAL NAME : Ethanol, 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-, hydrochloride CAS REGISTRY NUMBER : 59652-29-8 LAST UPDATED : 199706 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C16-H23-N-O2.Cl-H MOLECULAR WEIGHT : 297.86 WISWESSER LINE NOTATION : T56 BOJ CYQ1MX1&1&1 I2 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 177 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 88 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29700 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22