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59652-29-8

59652-29-8 structure
59652-29-8 structure
  • Name: Bufuralol
  • Chemical Name: (+/-)-bufuralol hydrochloride
  • CAS Number: 59652-29-8
  • Molecular Formula: C16H24ClNO2
  • Molecular Weight: 297.82000
  • Create Date: 2018-05-01 08:00:00
  • Modify Date: 2025-08-25 18:13:55
  • Bufuralol, also known as Ro-34787, is a β-adrenoceptor antagonist with partial agonist activity and is potentially useful for the treatment of hypertension. It is metabolized by CYP2D6. Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor.
Name (+/-)-bufuralol hydrochloride
Synonyms a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol
Bufuralol HCl
AngiumHCl
2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-ethanohydrochloride
2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)ethanolhydrochloride
BUFURALOL,HYDROCHLORIDE
bufurololhydrochloride
ANGIUM
ro3-4787
Melting Point 143-146ºC
Molecular Formula C16H24ClNO2
Molecular Weight 297.82000
Exact Mass 297.15000
PSA 45.40000
LogP 4.60960

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KK0207500
CHEMICAL NAME :
Ethanol, 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-, hydrochloride
CAS REGISTRY NUMBER :
59652-29-8
LAST UPDATED :
199706
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H23-N-O2.Cl-H
MOLECULAR WEIGHT :
297.86
WISWESSER LINE NOTATION :
T56 BOJ CYQ1MX1&1&1 I2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
177 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
88 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29700 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1410,1977
Hazard Codes Xn
Risk Phrases 22
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