35891-70-4

• 常用中文名：嗜热菌杀酵母素
• 常用英文名：Myriocin
• CAS号：35891-70-4
• 分子式：C₂₁H₃₉NO₆
• 分子量：401.538
• 相关类别： 研究领域 其他
• 发布时间：2018-08-28 19:07:10
• 更新时间：2026-07-02 10:01:24
• Myriocin 是一种从 Myriococcum albomyces, Isaria sinclairi 和 Mycelia sterilia 中分离的真菌代谢产物,是一种有效的丝氨酸-棕榈酰转移酶 (serine-palmitoyl-transferase) 抑制剂,是鞘脂从头合成的关键。Myriocin 强烈抑制亚基因组 HCV-1b 复制子和基因型 2a 感染性 HCV 的 JFH-1 株的复制,抑制 HCV 感染的 IC50 为 3.5 μg/mL。

名称

• 中文名: 嗜热菌杀酵母素
• 英文名: myriocin
• 中文别名: 多球壳菌素, 来源于无孢霉群; Myriocin 多球壳菌素（子囊霉素）; 杀酵母嗜热菌素; 多球壳素; 多壳球孢菌素; 2S,3R,4R,6E-2-氨基-3,4-二羟基-2-羟甲基L-14-氧-6-二十烯酸/多壳球菌素/嗜热菌杀酵母素/多球壳素/多壳球孢菌素/(+)-多球壳菌素/子囊霉素; Myriocin 多球壳菌素(子囊霉素); 多球壳菌素/嗜热菌杀酵母素; 多球壳菌素; 2S,3R,4R,6E-2-氨基-3,4-二羟基-2-羟甲基L-14-氧-6-二十烯酸; 多壳球菌素; 子囊霉素,来源于菌丝体; (+)-多球壳菌素; 多球壳菌素(2S,3R,4R,6E-2-氨基-3,4-二羟基-2-羟甲基L-14-氧-6-二十烯酸、嗜热菌杀酵母素、多球壳素); MYRIOCIN (ISP-I),SERINE PALMITOYLTRANSFERASE抑制剂; 嗜热菌杀酵母素(来源于无孢霉群)
• 英文别名: MYRIOCIN; 6e))-4s; (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-icosenoic acid; ISP-I; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxyMethyl-14-oxoeicos-6-enoic Acid; [2S,3R,4R]-(E)-2-AMINO-3,4-DIHYDROXY-2-[HYDROXYMETHYL]-14-OXO-6-EICOSENOIC ACID; ISP-I, Thermozymocidin, (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid; [2S,3R,4R,6E]-2-AMINO-3,4-DIHYDROXY-2-[HYDROXYMETHYL]-14-OXO-6-EICOSENOIC ACID; Thermozymocidin, ISP-I, (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; Myriocin,Mycelia sterilia; Myriocin, Mycelia sterilia - - Calbiochem; (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid; Isp-1 suppressant; THERMOZYMOCIDIN; (2S,3R,4R,E)-2-amino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxoicos-6-enoic acid; ISP-I NSC 177379 Myriocin Thermozymocidin; Myriocin (ISP-1); 6-Eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2S,3R,4R,6E); Thermozymocidin; ISP-1; 2-Amino-2-hydroxymethyl-3,4-dihydroxy-14- oxoeicos-6-enoic acid; Myriocin (ISP-I), serine palmitoyltransferase inhibitor; TherMozyMocidin, ISP 1; 6-eicosenoicacid,2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-,(2s-(2r*,3s; ISP-I|||Thermozymocidin; Myriocin from Mycelia sterilia; MFCD01632772; C001996; Spi-1 inhibitor; MYRIOCIN, MYCELIA STERILIA; antibiotic ISP-I; 2-[(1R,2R,4E)-1,2-Dihydroxy-12-oxo-4-octadecen-1-yl]-D-serine; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxo-6-eicosenoic Acid; Myriocin (Thermozymocidin); MYRIOCIN FROM MYCELIA STERILIA

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 636.7±55.0 °C at 760 mmHg
• 分子式: C₂₁H₃₉NO₆
• 分子量: 401.538
• 闪点: 338.8±31.5 °C
• 精确质量: 401.277740
• PSA: 141.08000
• LogP: 4.21
• 蒸汽压: 0.0±4.3 mmHg at 25°C
• 折射率: 1.522
• 储存条件: -20℃
• 计算化学:

  1.疏水参数计算参考值（XlogP）:-0.1

  2.氢键供体数量:5

  3.氢键受体数量:7

  4.可旋转化学键数量:18

  5.互变异构体数量:3

  6.拓扑分子极性表面积141

  7.重原子数量:28

  8.表面电荷:0

  9.复杂度:468

  10.同位素原子数量:0

  11.确定原子立构中心数量:3

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:1

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Myriocin 是一种从 Myriococcum albomyces, Isaria sinclairi 和 Mycelia sterilia 中分离的真菌代谢产物,是一种有效的丝氨酸-棕榈酰转移酶 (serine-palmitoyl-transferase) 抑制剂,是鞘脂从头合成的关键。Myriocin 强烈抑制亚基因组 HCV-1b 复制子和基因型 2a 感染性 HCV 的 JFH-1 株的复制,抑制 HCV 感染的 IC50 为 3.5 μg/mL。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 靶点:

  Serine-palmitoyl-transferase (SPT)[1]

• 参考文献:

  [1]. He Q, et al. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes inductionof c-myc in mouse liver. Mycopathologia. 2004 Apr;157(3):339-47.

  [2]. Amemiya F, et al. Targeting lipid metabolism in the treatment of hepatitis C virus infection. J Infect Dis. 2008 Feb 1;197(3):361-70.

  [3]. Ciesek S, et al. The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis. 2008 Oct 1;198(7):1091-3.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : JX3890000 CHEMICAL NAME : 6-Eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2S-(2R*,3S*,4S*,6E))- CAS REGISTRY NUMBER : 35891-70-4 LAST UPDATED : 198910 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H39-N-O6 MOLECULAR WEIGHT : 401.61 WISWESSER LINE NOTATION : Q1XZVQYQYQ2U7V6 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,109,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,109,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,109,1972 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 250 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,2067,1978

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xi; Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: UN 2811 6.1/PG 3
• WGK德国: 3.0
• RTECS号: JX3890000
• 危险类别: 6.1

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