毒理学数据:
1。
试验方法：口服
摄入剂量： 1500毫克/千克
测试对象：人力-儿童
毒性类型：急性
毒性作用： 详细的毒副作用没有报告以外的其他致死剂量值
2 。
试验方法：口服
摄入剂量： 1042年mg/kg/13W-I
测试对象：人-人
毒性类型：急性
毒性作用： 1.视神经病变
2. -视野变化
3 。试验方法：口服
摄入剂量： 48毫克/千克
测试对象：人力-儿童
毒性类型：急性
毒性作用： 1.厌食症（人）
2.甲状腺重量（甲状腺肿）
3.体重减轻或减少体重增加
生态学数据:
该物质对环境可能有危害，对水体应给予特别注意。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GF9800000
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CHEMICAL NAME :
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Cobalt(II) chloride
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CAS REGISTRY NUMBER :
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7646-79-9
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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44
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MOLECULAR FORMULA :
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Cl2-Co
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MOLECULAR WEIGHT :
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129.83
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WISWESSER LINE NOTATION :
-
CO G2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Human - child
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DOSE/DURATION :
-
48 mg/kg
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TOXIC EFFECTS :
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Behavioral - anorexia (human) Endocrine - thyroid weight (goiter) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Human - child
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DOSE/DURATION :
-
1500 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Human - man
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DOSE/DURATION :
-
1042 mg/kg/13W-I
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TOXIC EFFECTS :
-
Sense Organs and Special Senses (Eye) - optic nerve neuropathy Sense Organs and Special Senses (Eye) - visual field changes
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
80 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
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2 gm/kg
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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17402 ug/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4300 ug/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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80 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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49 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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23300 ug/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
-
Mammal - dog
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DOSE/DURATION :
-
36 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rabbit
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DOSE/DURATION :
-
1272 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
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SPECIES OBSERVED :
-
Rodent - rabbit
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DOSE/DURATION :
-
200 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
-
55 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
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165 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Intraperitoneal
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
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165 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
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1003 mg/kg/30W-I
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TOXIC EFFECTS :
-
Behavioral - alteration of classical conditioning
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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60 mg/kg/3D-I
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Intravenous
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SPECIES OBSERVED :
-
Mammal - dog
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DOSE/DURATION :
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1150 mg/kg/10W-I
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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400 mg/kg/19D-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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11 mg/kg
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SEX/DURATION :
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female 1-22 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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30 gm/kg
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SEX/DURATION :
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female 15-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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7280 mg/kg
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SEX/DURATION :
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male 13 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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25 mg/kg
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SEX/DURATION :
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female 10 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
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TYPE OF TEST :
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Specific locus test
MUTATION DATA
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TYPE OF TEST :
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DNA damage
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TEST SYSTEM :
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Mammal - species unspecified Lymphocyte
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DOSE/DURATION :
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750 umol/L
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REFERENCE :
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SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 198,513,1977 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,363,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,363,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,363,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84329 No. of Facilities: 267 (estimated) No. of Industries: 13 No. of Occupations: 12 No. of Employees: 2790 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84329 No. of Facilities: 185 (estimated) No. of Industries: 9 No. of Occupations: 13 No. of Employees: 9392 (estimated) No. of Female Employees: 4192 (estimated)
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