480-79-5

• 常用中文名：全缘千里光碱
• 常用英文名：Integerrimine
• CAS号：480-79-5
• 分子式：C₁₈H₂₅NO₅
• 分子量：335.39500
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-08-13 09:24:25
• 更新时间：2024-01-09 11:53:08
• (-)-整合子嘧啶,一种吡咯里西啶生物碱,具有抗溃疡活性。(-)-整合子亚胺也是果蝇中的一种致突变和弱致碎屑剂[1][2]。

名称

• 中文名: 全緣千里光鹼
• 英文名: Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl(1,6)dioxacyclododecino(2,3,4-gh)
• 英文别名: Intergerrimine; senecionyne; Squalidine; INTEGERRIMINE; seneciionine; 12-hydroxy-senecionane-11,16-dione

物化性质

• 密度: 1.25g/cm3
• 沸点: 563.7ºC at 760 mmHg
• 熔点: 172 °C
• 分子式: C₁₈H₂₅NO₅
• 分子量: 335.39500
• 闪点: 294.7ºC
• 精确质量: 335.17300
• PSA: 76.07000
• LogP: 1.13070
• 蒸汽压: 4.68E-15mmHg at 25°C
• 折射率: 1.57
• 储存条件: -20°C，干燥，密封

生物活性

• 描述: (-)-整合子嘧啶,一种吡咯里西啶生物碱,具有抗溃疡活性。(-)-整合子亚胺也是果蝇中的一种致突变和弱致碎屑剂[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: (-)-整合子亚胺(0.00625-0.05 mM)在果蝇体细胞中也必须具有诱变活性。(-)-整合素亚胺通常需要细胞色素P450依赖性代谢激活来显示遗传毒性活性[1]。
• 参考文献:

  [1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7.

  [2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NM9080000 CHEMICAL NAME : Integerrimine CAS REGISTRY NUMBER : 480-79-5 LAST UPDATED : 199603 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C18-H25-N-O5 MOLECULAR WEIGHT : 335.44 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg/20D-I TOXIC EFFECTS : Related to Chronic Data - death MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 18750 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)