23668-11-3

• 常用中文名：密旋霉素
• 常用英文名：Pactamycin
• CAS号：23668-11-3
• 分子式：C₂₈H₃₈N₄O₈
• 分子量：558.62300
• 发布时间：2018-12-10 21:42:28
• 更新时间：2026-07-01 17:44:00
• Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act

名称

• 中文名: 密旋霉素
• 英文名: Benzoic acid,2-hydroxy-6-methyl-,[(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methylester
• 中文别名: 帕塔霉素; 帕他霉素; 帕坦霉素
• 英文别名: 2-Hydroxy-6-methylbenzoic acid [[(1S)-5α-(3-acetylphenylamino)-4β-amino-3β-(3,3-dimethylureido)-1β,2α-dihydroxy-3-[(S)-1-hydroxyethyl]-2-methylcyclopentan-1α-yl]methyl] ester; 2-Hydroxy-6-methylbenzoic acid [(1S)-5α-[(3-acetylphenyl)amino]-4β-amino-3β-[[(dimethylamino)carbonyl]amino]-1β,2α-dihydroxy-3-[(S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester; A 80856F30; 2-Hydroxy-6-methylbenzoic acid [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester; NSC52947; Benzoic acid, 2-hydroxy-6-methyl-, [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester; PNU-0015800; U-15800

物化性质

• 密度: 1.38g/cm3
• 沸点: 784.2ºC at 760mmHg
• 分子式: C₂₈H₃₈N₄O₈
• 分子量: 558.62300
• 闪点: 428.1ºC
• 精确质量: 558.26900
• PSA: 194.68000
• LogP: 1.91870
• 蒸汽压: 6.66E-26mmHg at 25°C
• 折射率: 1.645

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RT0790000 CHEMICAL NAME : Pactamycin CAS REGISTRY NUMBER : 23668-11-3 LAST UPDATED : 199504 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C28-H38-N4-O8 MOLECULAR WEIGHT : 558.70 WISWESSER LINE NOTATION : L5TJ AYQ1 AMVN1&1 BQ B1OVR CQ F1& CQ C1 DMR CV1& EZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 ug/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - other changes Liver - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 14 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15600 ug/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - other changes Liver - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 750 ug/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - other changes Liver - other changes MUTATION DATA TEST SYSTEM : Rodent - rat DOSE/DURATION : 6 mg/kg REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 11,311,1975 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300-H315-H319-H335
• 警示性声明: P261-P264-P301 + P310-P305 + P351 + P338
• 危险品运输编码: UN 2811 6.1 / PGII