3306-60-3

• 常用中文名：COLCHICINE, O(sup 1)-DEMETHYL-, ACETATE
• 常用英文名：COLCHICINE, O(sup 1)-DEMETHYL-, ACETATE
• CAS号：3306-60-3
• 分子式：C₂₃H₂₅NO₇
• 分子量：427.44700
• 发布时间：2016-11-25 13:46:57
• 更新时间：2024-02-03 22:22:16

名称

• 英文名: [(7S)-7-acetamido-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-1-yl] acetate
• 英文别名: 1-O-acetyl-1-O-demethyl-colchicine; 1-Demethyl-1-acetylcolchicine

物化性质

• 密度: 1.29g/cm3
• 沸点: 729.6ºC at 760 mmHg
• 分子式: C₂₃H₂₅NO₇
• 分子量: 427.44700
• 闪点: 395ºC
• 精确质量: 427.16300
• PSA: 100.16000
• LogP: 3.17920
• 折射率: 1.587

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0881000 CHEMICAL NAME : Colchicine, O(sup 1)-demethyl-, acetate CAS REGISTRY NUMBER : 3306-60-3 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C23-H25-N-O7 MOLECULAR WEIGHT : 427.49 WISWESSER LINE NOTATION : L B677 MV&T&J COV1 DO1 EO1 JMV1 OO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 88 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

合成路线

64-86-8 75-36-5 ~34% 3306-60-3

文献：McDonald, Edward; Ramage, Robert; Woodhouse, Robert N.; Underbill, Edward W.; Wetter, Leslie R.; Battersby, Alan R. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 18 p. 2979 - 2987

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