87424-25-7

87424-25-7结构式

常用中文名：(S)-N-(3-羟基-1,2-二甲氧基-10-(甲基硫代)-9-氧代-5,6,7,9-四氢苯并[A]庚烷-7-基)乙酰胺
常用英文名：3-demethylthiocolchicine
CAS号：87424-25-7
分子式：C₂₁H₂₃NO₅S
分子量：401.47600
发布时间：2016-02-06 06:43:28
更新时间：2026-07-10 23:23:09

中文名	(S)-N-(3-羟基-1,2-二甲氧基-10-(甲基硫代)-9-氧代-5,6,7,9-四氢苯并[A]庚烷-7-基)乙酰胺
英文名	N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
中文别名	硫秋水仙苷杂质B 硫秋水仙素杂质C 硫秋水仙苷杂质C 3-去甲基硫秋水仙碱
英文别名	Desmethyl thiocolchicine N-((S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide 3-Desmethylthiocolchicine 3-O-Desmethyl Thiocolchicine (S)-7-Acetylamino-3-hydroxy-1,2-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on 3-O-demethylthiocolchicine 2-Demethylthio-colchicine Colchicine,O(sup 3)-demethyl-10-thio (7S)-1,2-Dimethoxy-3-hydroxy-10-(methylthio)-7α-(acetylamino)-5,6,7,9-tetrahydrobenzo[a]htalene-9-one Acetamide,N-((7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl) 3-Demthylthiocolchicine Thiocolchicoside Impurity B Thiocolchicoside Impurity C (S)-1-Methoxy-2-methyloxy-3-hydroxy-7-acetylamino-10-methylthio-6,7-dihydrobenzo[a]htalen-9(5H)-one Acetamide,N-(5,6,7,9-tetrahydro-1,2-dimethoxy-3-hydroxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-,(S) Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]htalen-7-yl] 3-O-Demethyl ThiocolchicineQ: What is 3-O-Demethyl Thiocolchicine Q: What is the CAS Number of 3-O-Demethyl Thiocolchicine Q: What is the storage condition of 3-O-Demethyl Thiocolchicine N-((S)-3-Hydroxy-1,2-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]htalen-7-yl]acetamide N-[(7S,12a)-3-hydroxy-1,2-dimethoxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl]acetamide (3-O-demethylthiocolchicine) (S)-N-(3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl)acetamide Thiocolchicoside Impurity C (3-O-Demethyl Thiocolchicine) O(sup 3)-Demethyl-10-thiocolchicine 3-O-DeMethylthiocolchicine N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-diMethoxy-10-(Methylthio)-9-oxobenzo[a]htalen-7-yl]acetaMide (S) N-[1,2-dimethoxy-3-hydroxy-10-methylthio-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]-acetamide

密度	1.33g/cm3
沸点	769ºC at 760 mmHg
熔点	>240ºC (dec.)
分子式	C₂₁H₂₃NO₅S
分子量	401.47600
闪点	418.9ºC
精确质量	401.13000
PSA	110.16000
LogP	3.67280
折射率	1.636

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8586000

CHEMICAL NAME :: Acetamide, N-(5,6,7,9-tetrahydro-1,2-dimethoxy-3-hydroxy-10-(met hylthio)-9-oxobenzo(a) heptalen-7-yl)-, (S)-

CAS REGISTRY NUMBER :: 87424-25-7

BEILSTEIN REFERENCE NO. :: 3176383

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H23-N-O5-S

MOLECULAR WEIGHT :: 401.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 28,1204,1985

2730-71-4

~58%

87424-25-7

文献：ALBERTA HEALTH SERVICES; NATIONAL RESEARCH COUNCIL OF CANADA; TUSZYNSKI, Jack; MANE, Jonathan Y.; HUZIL, John Torin; TOMANEK, Boguslaw; BARTUSIK, Darota Patent: WO2011/22805 A1, 2011 ; Location in patent: Page/Page column 78 ;