10085-81-1

• 常用中文名：盐酸苄辛胺
• 常用英文名：Benzoctamine Hydrochloride
• CAS号：10085-81-1
• 分子式：C₁₈H₂₀ClN
• 分子量：285.81100
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-05-14 08:00:00
• 更新时间：2024-01-10 20:04:47
• Benzoctamine hydrochloride (Ba-30803) 是一种具有抗焦虑作用的精神活性药物。Benzoctamine hydrochloride阻断中枢突触后 5-羟色胺受体,并可降低脑内5-HT的周转。

名称

• 中文名: 盐酸苯佐卡因
• 英文名: Benzoctamine hydrochloride
• 英文别名: Benzoctamine HCl; Tacitin; Tacitine; EINECS 233-216-0; BA 30,803

物化性质

• 沸点: 372ºC at 760mmHg
• 分子式: C₁₈H₂₀ClN
• 分子量: 285.81100
• 闪点: 181.1ºC
• 精确质量: 285.12800
• PSA: 12.03000
• LogP: 4.62410
• 蒸汽压: 9.91E-06mmHg at 25°C
• 储存条件: 通风低温干燥

生物活性

• 描述: Benzoctamine hydrochloride (Ba-30803) 是一种具有抗焦虑作用的精神活性药物。Benzoctamine hydrochloride阻断中枢突触后 5-羟色胺受体,并可降低脑内5-HT的周转。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 体内研究: 苯并辛胺盐酸盐(Ba-30803)抑制L-5-羟色胺(5-HTP)诱导的小鼠头部抽搐反应和5-甲氧基色胺(5-MT)预处理的大鼠头部抽搐反应。苯并辛胺也能拮抗色胺(TRP)诱导的大鼠前爪阵挛性惊厥[2]。
• 参考文献:

  [1]. Lippmann W, et al. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974;51(4):571-575.

  [2]. Przegaliński E, et al. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978;30(6):781-790.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KJ4550000 CHEMICAL NAME : 9,10-Ethanoanthracene-9-(10H)-methylamine, N-methyl-, hydrochloride CAS REGISTRY NUMBER : 10085-81-1 LAST UPDATED : 199506 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C18-H19-N.Cl-H MOLECULAR WEIGHT : 285.84 WISWESSER LINE NOTATION : L6 H666/GP 2AF P&&TTJ G1M1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 26 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,336,1972 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 51 mg/kg SEX/DURATION : female 2-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927- Volume(issue)/page/year: 49,1309,1973