196618-13-0

• 常用中文名：奥司他韦
• 常用英文名：Oseltamivir
• CAS号：196618-13-0
• 分子式：C₁₆H₂₈N₂O₄
• 分子量：312.40
• 相关类别： 原料药 人工合成抗感染类药 抗病毒类药
• 发布时间：2018-07-02 17:20:36
• 更新时间：2026-07-02 21:19:54
• 奥司他韦(GS4104)是一种口服活性流感病毒神经氨酸酶抑制剂(NAI)。奥司他韦抑制A/H3N2、A/H1N2、A/H1N1和B型流感病毒,平均IC50分别为0.67、0.9、1.34和13nM[1]。

名称

• 中文名: 奥司他韦
• 英文名: oseltamivir
• 中文别名: 达菲; 奥司他韦 标准品; 奧司他韦; 乙腈中奥司他韦; 奥斯他韦中间体; (3R,4R,5S)-4-乙酰氨基-5-氨基-3-(戊-3-基氧基)环己-1-烯羧酸乙酯; 奥司他韦(含磷酸盐); 奧司他韦(BASE); 奥塞米韦; OSELTAMIVIR奥司他韦; 奥司他韦检测标准品; 甲醇中奥司他韦; (3R,4R,5S)-4-乙酰氨基-5-氨基-3-(戊烷-3-基氧基)环己-1-烯甲酸乙酯(奥司他韦杂质); 奥司他韦磷酸酯; (3R,4R,5S)-4-乙酰胺基-5-氨基-3-(1-乙基丙氧基)-1-环己烯-1-甲酸乙酯; 奥司他韦酸-13CD3杂质
• 英文别名: (3R, 4R, 5S) -4-acetylamino-5-amino-3- (1-ethylpropoxy)-Ethyl 1-cyclohexene-1-formate; GOP-A-Flu; TaMiflu-Free; (3R,4R,5S)-Ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecboxylate (Oseltamivir Impurity); ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate; Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3- yloxycyclohexene-1-cboxylate; (3R,4R,5S)-Ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecboxylate; ethyl (3R,4R,5S)-5-aMino-4-acetaMido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate; (3R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate; [14C]-Oseltamivir; Ostavir; Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(3-pentanyloxy)-1-cyclohexene-1-cboxylate phosphate; Ethyl (3R, 4R, 5S) - 4-acetylamino-5-amino-3 - (1-ethylpropoxy) - 1-cyclohexen-1-formate; (3R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecboxylate; (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester; ethyl (3R,4R,5S)-5-amino-4-acetaMido-3-(pentan-3-yloxy)cyclohex-1-ene-1-cboxylate; Oseltamivir D3Q: What is Oseltamivir D3 Q: What is the CAS Number of Oseltamivir D3 Q: What is the storage condition of Oseltamivir D3 Q: What e the applications of Oseltamivir D3; OSELTAMIVIR //BP; GS 4104; (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester; Oseltamivir (free base); Oseltamivr; TaMvir; OSTELTAMIVIR; 1-Cyclohexene-1-cboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R,4R,5S); Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-cboxylate; OSELTAMIVIR; TAMIFLU; (-)-Oseltamivir; Oseltamivir 100 μg/mL in Acetonitrile; (3R,4R,5S)-4-acetylamino-5-amino-3(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 445.4±55.0 °C at 760 mmHg
• 熔点: 109 °C
• 分子式: C₁₆H₂₈N₂O₄
• 分子量: 312.40
• 闪点: 223.2±31.5 °C
• 精确质量: 312.204895
• PSA: 90.65000
• LogP: 2.52
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.529
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热

生物活性

• 描述: 奥司他韦(GS4104)是一种口服活性流感病毒神经氨酸酶抑制剂(NAI)。奥司他韦抑制A/H3N2、A/H1N2、A/H1N1和B型流感病毒,平均IC50分别为0.67、0.9、1.34和13nM[1]。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 体内研究: 奥司他韦(20 mg/kg/天,口服,每天两次,持续 10天) 可预防 H1N1pdm病毒感染小鼠的死亡[2] 奥司他韦(10 mg/kg/天,口服灌胃,5.天) 联合 金刚烷胺(HY-B0402)(15或30 mg/kg)对小鼠 H5N1流感病毒感染的保护效果优于单一疗法[3] 奥司他韦还可与 利巴韦林(HY-B0434),或 法维匹拉韦(HY-14768),或培拉米韦(HY-17015A)一起用于预防小鼠流感病毒感染[4] [5]
• 参考文献:

  [1]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8.

  [2]. Smee DF, et al. Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50.

  [3]. Ilyushina NA, et al. Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice. Antivir Ther. 2007;12(3):363-70.

  [4]. Ilyushina NA, et al. Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob Agents Chemother. 2008 Nov;52(11):3889-97.

  [5]. Smee DF, et al. Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 2010 Oct;88(1):38-44.

合成路线

上下游产品

上游产品  6
312904-18-0 204255-06-1 1041262-68-3 367252-68-4
1443055-49-9 64-17-5
下游产品  1
204255-11-8