28649-59-4

• 常用中文名：千金子甾醇，千金子素L1
• 常用英文名：Euphorbiasteroid
• CAS号：28649-59-4
• 分子式：C₃₂H₄₀O₈
• 分子量：552.655
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-09-28 16:22:27
• 更新时间：2026-07-23 00:35:33
• Euphorbiasteroid 是续随子中的三环二萜,可抑制 tyrosinase 活性,增强 AMPK 的磷酸化,具有抗癌、抗病毒、抗肥胖及多重耐药调节作用。

名称

• 中文名: 千金子甾醇
• 英文名: euphorbiasteroid(p)
• 中文别名: 血桐; 化合物:Euphorbiasteroid; (1,4,6S,7S,7,8S,9R,11AS,E)-1,1,3,6-四甲基-4-氧代-7-(2-苯基乙酰氧基)-1,1A,4,6,7,7A,8,10,11,11A-十氢螺[环戊并[A]环丙并[F]轮烯-9,2'-环氧乙烷]-4A,8(5H)-二基 二乙酸酯; Euphorbiasteroid :千金子甾醇; 化合物：Euphorbiasteroid; Euphobiasteroid 千金子甾醇; 千金子甾醇, 来源于千金子; 千金子甾醇Euphorbiasteroid; 千金子甾醇标准品; 千金子甾醇对照品; 千金子甾醇(千金子素L1)(标定对照品); E千金子甾醇 标准品; 续随二萜酯; 千金子甾醇,10 MM DMSO 溶液; 千金子甾醇,千金子素L1; 千金子甾醇(分析标准品); 千金子素L1; EUPHOBIASTEROID 千金子甾醇
• 英文别名: (1aS,2E,4,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3; Benzeneacetic acid, (1aR,2E,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester; (1aS,2E,4,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f]annulene-9,2'-oxiran]-7-yl phenylacetate; Euphorbia factor L1; Euphorbiasteroid（EuphorbiaFactor L1）; Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester; (1,4,6S,7S,7,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate; Daughter son sterol; Euphorbiasteroid, 10 mM in DMSO; Epoxylathyrol; euphorbiasteroid; Benzeneacetic acid, (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester; 6,20-oxylathyrol phenylacetate diacetate; Benzeneacetic acid (1,2'R,2E,4,6S,7S,7,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester; Euphorbiasteroid from Ltochloa chinensis (L.) Nees; 6,20-Epoxylathyrol-5,10-diacetat-3-phenylacetat; (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate; (1aR,2E,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate; 1,10-epoxyaristolane

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 633.1±55.0 °C at 760 mmHg
• 分子式: C₃₂H₄₀O₈
• 分子量: 552.655
• 闪点: 263.9±31.5 °C
• 精确质量: 552.272339
• PSA: 108.50000
• LogP: 5.55
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.566

生物活性

• 描述: Euphorbiasteroid 是续随子中的三环二萜,可抑制 tyrosinase 活性,增强 AMPK 的磷酸化,具有抗癌、抗病毒、抗肥胖及多重耐药调节作用。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Park SJ, et al. Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells via activation of AMP-activated protein kinase. Cell Biochem Funct. 2015 Jun;33(4):220-5.

安全

• 安全声明 (欧洲): 24/25
• 海关编码: 29061990