93129-94-3

• 常用中文名：他骨化醇一水物
• 常用英文名：Tacalcitol monohydrate
• CAS号：93129-94-3
• 分子式：C₂₇H₄₆O₄
• 分子量：434.652
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2018-02-11 08:00:00
• 更新时间：2026-07-03 13:00:09
• Tacalcitol一水合物能通过调节钙离子促进骨发育。

名称

• 中文名: 他卡西妥一水物
• 英文名: 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate , (1R,3S,5Z)
• 中文别名: (1S,3R,Z)-5-(2-((1R,3AS,7,E)-1-((2R,5R)-5-羟基-6-甲基庚烷-2-基)-7A-甲基八氢-4H-茚-4-亚基)亚乙基)-4-亚甲基环己烷-1,3-二醇水合物; 他骨化醇一水物/TACALCITOL MONOHYDRATE; 他卡西醇一水物; 他卡西妥一水合物; (1a,3b,5Z,7E,24R)-9,10-开环胆甾-5,7,10(19)-三烯-1,3,24-三醇一水合物; 他骨化醇一水物/93-3; 他卡西醇一水合物; 1,3-环己二醇,4-亚甲基-5-[(2E)-2-[(1R,3AS,7-八氢-1-[(1R,4R)-4-羟基-1,5-二甲基己基]-7A-甲基-4H-茚-4-亚基]亚乙基]-水合物(1:1),(1R,3S,5Z); (1α,3β,5Z,7E,24R)-9,10-开环胆甾-5,7,10(19)-三烯-1,3,24-三醇一水合物
• 英文别名: (1R,3S)-5-[2-[(1R,3,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-htan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol; 1,24(R)-DihydroxyvitaMin D3, Monohydrate; 1α,24(R)-Dihydroxycholecalciferol monohydrate; 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate , (1R,3S,5Z); CB91456900; Tacalcitol (monohydrate); (1R,3S)-5-[2-[(1R,3AR,7AS)-1-[(2R,5S)-5-HYDROXY-6-METHYL-HEPTAN-2-YL]-7A-METHYL-2,3,3A,5,6,7-HEXAHYD; 9,10-Secocholesta-5,7,10-triene-1,3,24-triol,Monohydrate, (1a,3b,5Z,7E,24R)- (9CI); (1R,3S)-5-[2-[(1R,3,7aS)-1-[(2R,5S)-5-hydroxy-6-Methyl-htan-2-yl]-7a-Methyl-2,3,3a,5,6,7-hexahyd; 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate (1:1), (1R,3S,5Z); 1α,24(R)-Dihydroxy-vitamin D3 monohydrate; (1R,3S,Z)-5-(2-((1R,3aS,7,E)-1-((2R,5R)-5-Hydroxy-6-methylhtan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate; 24(R)-Dihydroxyvitamin D3 monohydrate; (1S,3R,5Z,7E,24R)-9,10-Secocholesta-5,7,10-triene-1,3,24-triol hydrate (1:1); 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-, hydrate (1:1); 1,24-dihydroxy Vitamin D3 (hydrate); 1-alpha,24(R)-Dihydroxyvitamin D3 monohydrate; Curatoderm monohydrate|||TV 02 monohydrate|||TV-02H monohydrate|||1,24(R)-Dihydroxyvitamin D3 monohydrate; 24(R)-Dihydroxyvitamin D3

物化性质

• 分子式: C₂₇H₄₆O₄
• 分子量: 434.652
• 精确质量: 434.339600
• PSA: 69.92000
• LogP: 5.49630
• 储存条件: 2-8℃

生物活性

• 描述: Tacalcitol一水合物能通过调节钙离子促进骨发育。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 其他
• 参考文献:

  [1]. Koyano K, Saitoh Y, Oshida J, Takimoto-Kamimura M.Dimer and superstructure of the active form of a vitamin D3; 1 alpha,24(R)dihydroxy-vitamin D3 monohydrate, C27O3H44.H2O.Chem Pharm Bull (Tokyo). 2001 Mar;49(3):305-11.

  [2]. Fukuoka et alTacalcitol, an active vitamin D3, induces nerve growth factor in human epidermal keratinocytes. Skin Pharmacol.Appl.Skin Physiol. (2001) 14 226.

  [3]. Rostowska-Nadolska et al Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblasts. Adv.Med.Sci. (2010) 55 86.