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138261-41-3生产厂家

138261-41-3价格

138261-41-3

138261-41-3结构式
138261-41-3结构式
  • 常用中文名:吡虫啉
  • 常用英文名:Imidacloprid
  • CAS号:138261-41-3
  • 分子式:C9H10ClN5O2
  • 分子量:255.661
  • 相关类别: 化学农药原药 杀虫剂 其他杀虫剂
  • 发布时间:2018-02-05 08:00:00
  • 更新时间:2024-01-02 19:46:04
  • Imidacloprid是一种有效且广泛使用的新烟碱类农药,用于控制谷物,蔬菜,茶叶和棉花的害虫。

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中文名 1-((6-氯吡啶-3-基)甲基)-3-硝基咪唑烷-2-亚胺
英文名 (E)-imidacloprid
中文别名 吡虫啉
英文别名 1-((6-chloropyridin-3-yl)methyl)-3-nitroimidazolidin-2-imine
MFCD01721131
EINECS 200-835-2
Imidacloprid
1-((6-Chloro-3-pyridinyl)methyl)-N-nitro-imidazolidinimine
描述 Imidacloprid是一种有效且广泛使用的新烟碱类农药,用于控制谷物,蔬菜,茶叶和棉花的害虫。
相关类别
体外研究 在脂肪细胞(3T3-L1),肝细胞(HepG2)和肌管(C2C12)细胞培养模型中,吡虫啉降低了胰岛素刺激的葡萄糖摄取。用吡虫啉处理减少了蛋白激酶B(AKT)的磷酸化,这是胰岛素信号传导的主要调节因子之一,而不改变总体AKT表达。吡虫啉降低了核糖体S6激酶(S6K)的磷酸化,这是AKT的下游靶标,也是胰岛素信号传导的反馈抑制剂[1]。
体内研究 高剂量的吡虫啉引起认知功能的恶化,特别是在幼鼠中,并且这种恶化可能与相关基因表达的变化有关。在婴儿模型组中,在2和8mg/kg剂量下以及在成年大鼠中以8mg/kg剂量显着减少学习活动。此外,发现GRIN1,SYP和GAP-43的表达水平无显着变化[2]。早期发展暴露于吡虫啉对斑马鱼的神经行为功能具有早期和持续影响。在幼虫中,两种剂量的发育性吡虫啉暴露显着降低了游泳活动。在青少年和成年鱼类中,吡虫啉的发育暴露显着降低了新的坦克探索和增加感觉运动对惊吓刺激的反应[3]。在20mg/kg /天时观察到体重增加的减少,并且在尸检时,在该剂量水平下肝脏,肾脏和肾上腺的相对体重也显着增加。在最高剂量暴露时,自发运动活性也降低,因为血液学和尿液参数没有显着变化。大剂量吡虫啉暴露的大鼠脑,肝,肾均有轻度病理改变[4]。 20mg/kg的吡虫啉在肝脏中产生SOD,CAT,GPx,GSH,LPO的显着变化;大脑中的SOD,CAT和GPx以及肾脏中的LPO [5]。高剂量的吡虫啉特异性抑制细胞介导的免疫应答,这可从DTH反应降低和T淋巴细胞对PHA的刺激指数降低中看出。在脾脏和肝脏中也观察到显着的组织病理学改变。小鼠足垫切片的组织病理学分析显示剂量相关的DTH反应抑制[6]。
动物实验 大鼠:成年女性分为四组。一组用作对照,并通过管饲法给予玉米油作为载体。向雌性大鼠给予3组5,10和20mg / kg /天的吡虫啉90天。在整个实验期间记录体重,食物消耗和临床毒性迹象。在初始和90天收集尿液用于尿液分析。每周对每组的个体动物进行称重并记录体重[4]。小鼠:吡虫啉每天以10,5或2.5mg / kg口服给药28天。体液和细胞免疫应答的具体参数,包括对绵羊红细胞的血凝抗体(HA)滴度(SRBC; T依赖性抗原),对SRBC的迟发型超敏反应(DTH)和响应于植物血凝素的T淋巴细胞增殖(PHA) )评估[6]。
参考文献

[1]. Kim J, et al. Imidacloprid, a neonicotinoid insecticide, induces insulin resistance. J Toxicol Sci. 2013;38(5):655-60.

[2]. Kara M, et al. Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model. Int J Exp Pathol. 2015 Oct;96(5):332-7.

[3]. Crosby EB, et al. Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. Neurotoxicol Teratol. 2015 May-Jun;49:81-90.

[4]. Bhardwaj S, et al. A 90 days oral toxicity of imidacloprid in female rats: morphological, biochemical and histopathological evaluations. Food Chem Toxicol. 2010 May;48(5):1185-90.

[5]. Kapoor U, et al. Effect of imidacloprid on antioxidant enzymes and lipid peroxidation in female rats to derive its No Observed Effect Level (NOEL). J Toxicol Sci. 2010 Aug;35(4):577-81.

[6]. Badgujar PC, et al. Immunotoxic effects of imidacloprid following 28 days of oral exposure in BALB/c mice. Environ Toxicol Pharmacol. 2013 May;35(3):408-18.

密度 1.6±0.1 g/cm3
沸点 442.3±55.0 °C at 760 mmHg
熔点 144ºC
分子式 C9H10ClN5O2
分子量 255.661
闪点 221.3±31.5 °C
精确质量 255.052307
PSA 89.04000
LogP -0.43
外观性状 固体;White to Light yellow powder to crystal
蒸汽压 0.0±1.1 mmHg at 25°C
折射率 1.706
储存条件 0-6°C
水溶解性 0.061 g/100mL at 20 ºC

SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: Imidacloprid
: Fluka
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No.: 138261-41-3


SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 1), H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn HarmfulR22
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal wordWarning
Hazard statement(s)
Harmful if swallowed.
Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
Avoid release to the environment.
Dispose of contents/ container to an approved waste disposal plant.
Supplemental Hazardnone
Statements
Other hazards - none

SECTION 3: Composition/information on ingredients
Substances
Formula: C9H10ClN5O2
Molecular Weight: 255,66 g/mol
CAS-No.: 138261-41-3
Hazardous ingredients according to Regulation (EC) No 1272/2008
ComponentClassificationConcentration
Imidacloprid
CAS-No.138261-41-3Acute Tox. 4; Aquatic Acute 1; <= 100 %
Aquatic Chronic 1; H302,
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Hydrogen chloride gas, nitrogen oxides (NOx)
Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) AppearanceForm: solid
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evapouration rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
LD50 Oral - rat - 410 mg/kg
LC50 Inhalation - rat - > 5.323 mg/m3
LD50 Dermal - rat - > 5.000 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: NJ0560000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

SECTION 12: Ecological information
Toxicity
no data available
Toxicity to fishLC50 - Oncorhynchus mykiss (rainbow trout) - 211 mg/l - 96 h
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: 3077IMDG: 3077IATA: 3077
UN proper shipping name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Imidacloprid)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Imidacloprid)
IATA:Environmentally hazardous substance, solid, n.o.s. (Imidacloprid)
Transport hazard class(es)
ADR/RID: 9IMDG: 9IATA: 9
Packaging group
ADR/RID: IIIIMDG: IIIIATA: III
Environmental hazards
ADR/RID: yesIMDG Marine pollutant: yesIATA: yes
Special precautions for user
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination
packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.

SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
Further information
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any


SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ0560000
CHEMICAL NAME :
2-Imidazolidinimine, 1-((6-chloro-3-pyridinyl)methyl)-N-nitro-
CAS REGISTRY NUMBER :
138261-41-3
LAST UPDATED :
199806
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H10-Cl-N5-O2
MOLECULAR WEIGHT :
255.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),15,1993
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5323 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),15,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),15,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
98 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S209,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4550 mg/kg/13W-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 36(1,pt2),64,1997

符号 GHS02 GHS07
GHS02, GHS07
信号词 Danger
危害声明 H225-H302-H312-H319-H332
警示性声明 P210-P280-P305 + P351 + P338
个人防护装备 Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲) N: Dangerous for the environment;Xn: Harmful;F: Flammable;
风险声明 (欧洲) R11
安全声明 (欧洲) 26-36-22
危险品运输编码 UN 2588
RTECS号 NJ0560000
包装等级 III
危险类别 6.1(b)
海关编码 2933399026
海关编码 2933399026