105102-22-5

• 常用中文名：莫美他松
• 常用英文名：Mometasone
• CAS号：105102-22-5
• 分子式：C₂₂H₂₈Cl₂O₄
• 分子量：427.4
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-06-27 14:46:45
• 更新时间：2026-06-30 19:33:15
• 莫米松是一种吸入性糖皮质激素。莫米松可用于痰中嗜酸性粒细胞水平低的轻度哮喘。莫米松具有研究慢性手部湿疹和鼻窦炎的潜力[1][2]。

名称

• 中文名: 莫美他松
• 英文名: mometasone
• 中文别名: 淫羊藿双甙; 莫美他松杂质G; 糠酸莫米松杂质06; 9,21-双氯-11beta,17alpha-双羟基-16alpha-甲基孕-1,4-二烯-3,20-二酮; 莫米他松; 糠酸莫米松杂质7(糠酸莫米松杂质G); 莫米松杂质; 莫美达松; 莫美他松(糠酸莫米松杂质); 莫米松(糠酸莫米松杂质G); 莫米松; 化合物:Mometasone; 莫美他松类似物1; 糠酸莫米他松杂质G; (11Β,16Α)-9,21-二氯-11,17-二羟基-16-甲基孕烷-1,4-二烯-3,20-二酮; 化合物：Mometasone; 莫美他松杂质; 莫米松杂质G; 糠酸莫米松-17-醇(杂质G); 2H3]-莫米松; 2H5]-莫米松; 糠酸莫米松杂质G(莫米松); 糠酸莫米松杂质G; 糠酸莫米松有关杂质 G
• 英文别名: Mometasone furoate impurity GQ: What is Mometasone furoate impurity G Q: What is the CAS Number of Mometasone furoate impurity G Q: What is the storage condition of Mometasone furoate impurity G Q: What e the applications of Mometasone furoate impurity G; Mometasone Furoate Impurity G/Mometasone; MFCD02683426; Mometasone Furoate Impurity 6; Mometasone //BP; Pregna-1,4-diene-3,20-dione, 9,21-dichloro-11,17-dihydroxy-16-methyl-, (11β,16α); MometasoneFuroateBase; MoMetasone (MoMetasone Furoate IMpurity G); Mometasone IMpurity; Mometason Furoate Impurity G; Pregna-1,4-diene-3,20-dione,9,21-dichloro-11,17-dihydroxy-16-methyl-,(11b,16a)-(9CI); Elocon; MOMETOSONE FUROATE; Mometaxone analogue 1; MoMetasone Furoate { CreaM}; 9a,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione; (11β,16α)-9,21-Dichloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; Mometasone Impurity G; Mometasone Furoate Impurity 7(Mometasone Furoate Impurity G); (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-triMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Mometasone Furoate Impurity S; iciins; Pregna-1,4-diene-3,20-dione, 9,21-dichloro-11,17-dihydroxy-16-methyl-, (11b,16a)- (9CI); 9,21-Dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione (Mometasone); MOMETASONE; Mometasone 105-5; Pregna-1,4-diene-3,20-dione, 9,21-dichloro-11,17-dihydroxy-16-methyl-, (11.beta.,16.alpha.); 1, 4-PREGNADIEN-9α, 21-DICHLORO-16α-METHYL-11β, 17α-DIOL-3, 20-DIONE; Mometasone Furoate Impurity G; Momentasone imp. G

物化性质

• 密度: 1.35g/cm3
• 沸点: 586.6ºC at 760mmHg
• 熔点: 220ºC (decomposes)
• 分子式: C₂₂H₂₈Cl₂O₄
• 分子量: 427.4
• 闪点: 308.5ºC
• 精确质量: 426.1364648
• PSA: 93.81000
• LogP: 4.86920
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 4.47E-18mmHg at 25°C
• 折射率: 1.603

生物活性

• 描述: 莫米松是一种吸入性糖皮质激素。莫米松可用于痰中嗜酸性粒细胞水平低的轻度哮喘。莫米松具有研究慢性手部湿疹和鼻窦炎的潜力[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 体内研究: 莫米松(0.1-3 mg/kg；经鼻)在最高测试剂量为3 mg/kg时抑制气道对雾化乙酰甲胆碱的敏感性增加,并在过敏性肺部炎症小鼠模型中剂量依赖性地抑制过敏原诱导的Penh增加[3]。
• 参考文献:

  [1]. Veien NK, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999 May;140(5):882-6.

  [2]. Lazarus SC, et al. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 May 23;380(21):2009-2019.

  [3]. Wyss D, et al. Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol. 2007 Sep;152(1):83-90.

合成路线

83881-08-7 ~84% 105102-22-5

文献：Draper, Richard W.; Bin, Hu; McPhail, Andrew T.; Puar, Mohindar S.; Vater, Eugene J.; Weber, Lois Tetrahedron, 1999 , vol. 55, # 11 p. 3355 - 3364

24916-90-3 ~% 105102-22-5

文献：Tetrahedron, , vol. 55, # 11 p. 3355 - 3364

上下游产品

上游产品  2
83881-08-7 24916-90-3
下游产品  0