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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：色霉素 A3
纯度：95.0%
规格：
联系人：徐经理
联系电话：13311869306

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Chromomycin A3
纯度：98.0%
规格：1mg/5mg/1g/1g
联系人：李先生
联系电话：18916172912

广东翁江化学试剂有限公司
广东省韶关市翁源县
产品名：色霉素A3
纯度：98.0%
规格：1mg
联系人：朱丽丹
联系电话：13927877242

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7059-24-7生产厂家

7059-24-7价格

7059-24-7

7059-24-7结构式

常用中文名：色霉素A3
常用英文名：Chromomycin A3
CAS号：7059-24-7
分子式：C₅₇H₈₂O₂₆
分子量：1183.25000
相关类别：原料药抗肿瘤药抗生素类抗肿瘤药
发布时间：2018-03-13 08:00:00
更新时间：2024-01-11 16:05:12
Chromomycin A3 是一种金黄色素型抗肿瘤抗生素。Chromomycin A3 与二价阳离子形成二聚体复合物,例如 Mg2+,其强烈结合富含 GC 的 DNA 序列以抑制 DNA 复制和转录。Chromomycin A3 具有多种用途,可作为人精子染色质,自噬诱导剂和凋亡抑制剂的染色剂。

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中文名	色霉素A3
英文名	chromomycin A3
中文别名	铬霉菌素A3 东洋霉素
英文别名	MFCD00043151 Chromoycin A3 antibioticb599 EINECS 230-348-0 TOYOMYCIN Olivomycin D CHROMOMYCIN A3 Chromomycin aburamycinb

描述	Chromomycin A3 是一种金黄色素型抗肿瘤抗生素。Chromomycin A3 与二价阳离子形成二聚体复合物,例如 Mg2+,其强烈结合富含 GC 的 DNA 序列以抑制 DNA 复制和转录。Chromomycin A3 具有多种用途,可作为人精子染色质,自噬诱导剂和凋亡抑制剂的染色剂。
相关类别	研究领域 >> 癌症信号通路 >> 其他 >> 其他
参考文献	[1]. Murase H, et al. Evaluation of simultaneous binding of Chromomycin A3 to the multiple sites of DNA by the new restriction enzyme assay. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1832-1835.

密度	1.43g/cm3
沸点	1147.6ºC at 760 mmHg
熔点	185℃
分子式	C₅₇H₈₂O₂₆
分子量	1183.25000
闪点	311.1ºC
精确质量	1182.51000
PSA	359.34000
LogP	1.54640
外观性状	黄色粉末
折射率	1.608
储存条件	一、贮存 2-8°储存。
分子结构	1、摩尔折射率：286.26 2、摩尔体积（m³/mol）：827.2 3、等张比容（90.2K）：2394.9 4、表面张力（dyne/cm）：70.2 5、极化率（10^-24cm³）：113.48
更多	一、物性数据性状：不可用密度（g/mL,25/4℃）：不可用相对蒸汽密度（g/mL,空气=1）：不可用熔点（ºC）：不可用沸点（ºC,常压）：不可用沸点（ºC,5.2kPa）：不可用折射率：不可用闪点（ºC）：不可用比旋光度（º）：不可用自燃点或引燃温度（ºC）：不可用蒸气压（kPa,25ºC）：不可用饱和蒸气压（kPa,60ºC）：不可用燃烧热（KJ/mol）：不可用临界温度（ºC）：不可用临界压力（KPa）：不可用油水（辛醇/水）分配系数的对数值：不可用爆炸上限（%,V/V）：不可用爆炸下限（%,V/V）：不可用溶解性：不可用

毒理学数据:

二、毒理学数据：

急性毒性：不可用。

生态学数据:

三、生态学数据：

1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GB7875000

CHEMICAL NAME :: Chromomycin A3

CAS REGISTRY NUMBER :: 7059-24-7

LAST UPDATED :: 199806

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C57-H82-O26

MOLECULAR WEIGHT :: 1183.39

WISWESSER LINE NOTATION :: L C666 DVT&&J BQ FYO1&VYQYQ1 M1 NQ LO- BT6OTJ DOV1 F1 EO- BT6OTJ DQ EO1 F1&& EO- BT6OTJ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1431 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 330 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 ug/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 750 ug/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Liver - fatty liver degeneration Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 125 ug/kg

SEX/DURATION :: female 6-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 500 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 125 ug/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2813,1985 *** REVIEWS *** TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

符号	GHS06, GHS08
信号词	Danger
危害声明	H300-H360
警示性声明	P201-P264-P301 + P310-P308 + P313
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T+,T
风险声明 (欧洲)	61-28
安全声明 (欧洲)	S28;S45;S53;S36/S37/S39
危险品运输编码	UN 3462 6.1/PG 1
WGK德国	3
RTECS号	GB7875000
包装等级	I
危险类别	6.1(a)