3567-08-6

• 常用中文名：格列布唑
• 常用英文名：Benzenesulfonamide,4-methoxy-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-
• CAS号：3567-08-6
• 分子式：C₁₃H₁₇N₃O₃S₂
• 分子量：327.42200
• 发布时间：2018-06-23 07:14:40
• 更新时间：2024-01-12 20:38:05

名称

• 中文名: 格列布唑
• 英文名: Glysobuzole
• 英文别名: 4-methoxy-benzenesulfonic acid-(5-isobutyl-[1,3,4]thiadiazol-2-ylamide); 5-<4-Methoxy-benzolsulfonylamino>-2-isobutyl-1,3,4-thiadiazol; N-(5-isobutyl-[1,3,4]thiadiazol-2-yl)-4-methoxy-benzenesulfonamide; 4-Methoxy-benzolsulfonsaeure-(5-isobutyl-[1,3,4]thiadiazol-2-ylamid); Isobuzole; Wy-2340; Isopamin; 5-<4-Methoxy-phenylsulfonylamino>-2-isobutyl-1,3,4-thiadiazol; SADA

物化性质

• 密度: 1.37g/cm3
• 沸点: 517.5ºC at 760mmHg
• 分子式: C₁₃H₁₇N₃O₃S₂
• 分子量: 327.42200
• 闪点: 266.8ºC
• 精确质量: 327.07100
• PSA: 117.80000
• LogP: 3.69980
• 折射率: 1.589

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DB2780000 CHEMICAL NAME : Benzenesulfonamide, N-(5-isobutyl-1,3,4-thiadiazol-2-yl)-p-methoxy- CAS REGISTRY NUMBER : 3567-08-6 BEILSTEIN REFERENCE NO. : 0295174 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C13-H17-N3-O3-S2 MOLECULAR WEIGHT : 327.45 WISWESSER LINE NOTATION : T5NN DSJ CMSWR DO1& E1Y1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 534 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 468 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - ataxia Endocrine - hypoglycemia Nutritional and Gross Metabolic - body temperature decrease REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,631,1962 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - nausea or vomiting REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 214 gm/kg/52W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 *** REVIEWS *** TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970

安全

• 海关编码: 2935009090

合成路线

503-74-2 79-19-6 98-68-0 ~% 3567-08-6

文献：O'Neal,J.B. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 617 - 626

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海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%