102771-12-0

• 常用中文名：奈立索泮
• 常用英文名：Nerisopam
• CAS号：102771-12-0
• 分子式：C₁₈H₁₉N₃O₂
• 分子量：309.36200
• 发布时间：2018-09-24 09:53:25
• 更新时间：2024-09-13 17:42:05

名称

• 中文名: 奈立索泮
• 英文名: 4-(7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepin-1-yl)aniline
• 英文别名: UNII-18Q4O339AG; Nerisopam; 1-(4-Aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine; 5H-2,3-Benzodiazepine,1-(4-aminophenyl)-7,8-dimethoxy-4-methyl; Nerisopam [INN]; 1-(4-Aminophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine

物化性质

• 密度: 1.22g/cm3
• 沸点: 475.4ºC at 760mmHg
• 分子式: C₁₈H₁₉N₃O₂
• 分子量: 309.36200
• 闪点: 241.3ºC
• 精确质量: 309.14800
• PSA: 69.20000
• LogP: 2.50780
• 蒸汽压: 3.34E-09mmHg at 25°C
• 折射率: 1.612

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DE8746050 CHEMICAL NAME : 5H-2,3-Benzodiazepine, 1-(4-aminophenyl)-7,8-dimethoxy-4-methyl- CAS REGISTRY NUMBER : 102771-12-0 LAST UPDATED : 199706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H19-N3-O2 MOLECULAR WEIGHT : 309.40 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 128 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 108 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 275 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 182 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989