7336-40-5

• 常用中文名：N-甲基-秋水仙碱
• 常用英文名：N-Methylcolchicine
• CAS号：7336-40-5
• 分子式：C₁₅H₁₆O₄
• 分子量：260.29
• 相关类别： 研究领域 其他
• 发布时间：2018-06-16 21:37:47
• 更新时间：2024-01-10 18:20:38
• Micromarin F 是由蛇床子素合成的。Micromarin F 针对 Balanus albicostatus 和 Bugula neritina 的 EC50 值为 10.93 和 12.38 μM。

名称

• 中文名: N-甲基-秋水仙碱
• 英文名: N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• 英文别名: N-Methylcolchicine; COLCHICINE,N-METHYL; Desacetylamino-N-methylcolchiceinamid; N-Acetyldemecolcine; N-methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide; N-acetyldemecoline; N-Methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid; N-Methyl-colchicin; N-Acetylcolchamine; Acetamide,N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl); N-Acetylcolcemid

物化性质

• 密度: 1.24g/cm3
• 沸点: 683.2ºC at 760 mmHg
• 分子式: C₁₅H₁₆O₄
• 分子量: 260.29
• 闪点: 367ºC
• 精确质量: 413.18400
• PSA: 74.30000
• LogP: 3.21380
• 折射率: 1.583
• 储存条件: 2-8°C，干燥，密封

生物活性

• 描述: Micromarin F 是由蛇床子素合成的。Micromarin F 针对 Balanus albicostatus 和 Bugula neritina 的 EC50 值为 10.93 和 12.38 μM。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Zhan-Chang Wang, et al. Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae. Int. J. Mol. Sci. 2013, 14.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0890000 CHEMICAL NAME : Colchicine, N-methyl- CAS REGISTRY NUMBER : 7336-40-5 BEILSTEIN REFERENCE NO. : 2825013 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C23-H27-N-O6 MOLECULAR WEIGHT : 413.51 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JN1&V1 NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3400 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2900 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1445 ug/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

安全

• 危害码 (欧洲): Xi

合成路线

477-30-5 108-24-7 ~95% 7336-40-5

文献：Hufford; Capraro; Brossi Helvetica Chimica Acta, 1980 , vol. 63, # 1 p. 50 - 56

7359-91-3 ~% 7336-40-5

文献：Santavy Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 2237,2242

186581-53-3 ~% 7336-40-5

文献：Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

186581-53-3 ~% 7404-91-3 7336-40-5

文献：Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

67-56-1 477-27-0 124-41-4 74-88-4 ~% 详细

文献：Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

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