477-27-0

• 常用中文名：原水仙碱
• 常用英文名：Colchiceine
• CAS号：477-27-0
• 分子式：C₂₁H₂₃NO₆
• 分子量：385.41000
• 发布时间：2018-10-01 15:47:19
• 更新时间：2025-08-22 19:20:26

名称

• 中文名: 原秋水仙碱
• 英文名: Colchiceine
• 中文别名: 10-去甲秋水仙碱; 原秋水仙鹼
• 英文别名: colchiceine

物化性质

• 密度: 1.31g/cm3
• 沸点: 731.5ºC at 760mmHg
• 熔点: 172-174ºC
• 分子式: C₂₁H₂₃NO₆
• 分子量: 385.41000
• 闪点: 396.2ºC
• 精确质量: 385.15300
• PSA: 94.09000
• LogP: 2.95950
• 蒸汽压: 1.83E-22mmHg at 25°C
• 折射率: 1.61
• 储存条件: 库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0520000 CHEMICAL NAME : Colchiceine CAS REGISTRY NUMBER : 477-27-0 BEILSTEIN REFERENCE NO. : 2824078 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C21-H23-N-O6 MOLECULAR WEIGHT : 385.45 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 43 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Blood - hemorrhage TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Sperm Morphology MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 250 nmol/L REFERENCE : AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 137,779,1990

安全

• 危害码 (欧洲): T+
• 海关编码: 2924299090

合成路线

3482-37-9 108-24-7 ~% 477-27-0

文献：Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261

73307-44-5 ~% 477-27-0

文献：Corrodi; Hardegger Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199

102419-93-2 ~% 477-27-0

文献：Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

209810-38-8 ~% 477-27-0

文献：Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102491-70-3 ~% 477-27-0

文献：Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102491-74-7 ~% 477-27-0

文献：Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102491-72-5 ~% 477-27-0

文献：Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102419-92-1 ~% 477-27-0

文献：Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

7469-68-3 ~% 477-27-0

文献：Corrodi; Hardegger Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199

上下游产品

上游产品  10
3482-37-9 108-24-7 73307-44-5 102419-93-2
209810-38-8 102491-70-3 102491-74-7 102491-72-5
102419-92-1 7469-68-3
下游产品  10
3476-50-4 3482-37-9 477-30-5 64-86-8
518-12-7 518-11-6 7404-91-3 7336-40-5
75491-24-6 75488-69-6

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%