801-52-5

• 常用中文名：泊非霉素
• 常用英文名：Porfiromycin
• CAS号：801-52-5
• 分子式：C₁₆H₂₀N₄O₅
• 分子量：348.35400
• 相关类别： 信号通路 细胞周期/DNA损伤 DNA烷基化剂/交联剂
• 发布时间：2018-08-13 22:07:27
• 更新时间：2026-08-15 17:18:06
• Porfiromycin是一种生物还原性烷基化剂,相对于其他需氧化合物,它优先杀死缺氧肿瘤细胞。

名称

• 中文名: 泊非霉素
• 英文名: Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)
• 中文别名: 卟啉霉素
• 英文别名: porphiromycin; Porfiromycine; porfemycin; 8-Azathioxanthine; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-, (1aS,8S,8,8bS); N-MethylMitoMycin C; RegaMycin; N-methylmitomycin C; Methylmitomycin; porfiromycin; (1aS,8S,8,8bS)-6-Amino-8-[[(aMinocbonyl)oxy]Methyl]-1,1a,2,8,8a,8b-hexahydro-8a-Methoxy-1,5-diMethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; ENT-50825; Methyl MitoMycin C; NCS-56410

物化性质

• 密度: 1.52g/cm3
• 沸点: 560.9ºC at 760 mmHg
• 分子式: C₁₆H₂₀N₄O₅
• 分子量: 348.35400
• 闪点: 293ºC
• 精确质量: 348.14300
• PSA: 127.96000
• 折射率: 1.672

生物活性

• 描述: Porfiromycin是一种生物还原性烷基化剂,相对于其他需氧化合物,它优先杀死缺氧肿瘤细胞。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂
• 参考文献:

  [1]. Keyes SR, Rockwell S, Sartorelli AC. Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res. 1985;45(8):3642-3645.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CN0525000 CAS REGISTRY NUMBER : 801-52-5 LAST UPDATED : 199709 DATA ITEMS CITED : 19 MOLECULAR FORMULA : C16-H20-N4-O5 MOLECULAR WEIGHT : 348.40 WISWESSER LINE NOTATION : T D3 B556 BN EN JV MVTTT&J E1 GO1 H1OVZ KZ L1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Blood - leukopenia Blood - thrombocytopenia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 68 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 88660 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 53500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 55 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Blood - granulocytopenia TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >10 mg/kg TOXIC EFFECTS : Blood - granulocytopenia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 84 mg/kg/28D-I TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 2 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,3939,1986

合成路线

50-07-7 74-88-4 ~62% 801-52-5

文献：Hanson, Robert N.; Hua, Edward; Labaree, David; Hochberg, Richard B.; Proffitt, Kyle; Essigmann, John M.; Croy, Robert G. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 42 p. 8501 - 8508

50-07-7 77-78-1 ~% 801-52-5

文献：Journal of the American Chemical Society, , vol. 113, # 12 p. 4634 - 4644

4055-39-4 ~% 801-52-5

文献：Journal of Organic Chemistry, , vol. 50, # 8 p. 1301 - 1302

18209-14-8 ~% 801-52-5

文献：Journal of Organic Chemistry, , vol. 50, # 8 p. 1301 - 1302

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