泊非霉素

• 常用名: 泊非霉素
• 英文名: Porfiromycin
• CAS号: 801-52-5
• 分子量: 348.35400
• 密度: 1.52g/cm3
• 沸点: 560.9ºC at 760 mmHg
• 分子式: C₁₆H₂₀N₄O₅
• 熔点: N/A
• 闪点: 293ºC

泊非霉素用途

Porfiromycin是一种生物还原性烷基化剂,相对于其他需氧化合物,它优先杀死缺氧肿瘤细胞。

泊非霉素名称

• 中文名: 泊非霉素
• 英文名: Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)

泊非霉素生物活性

• 描述: Porfiromycin是一种生物还原性烷基化剂,相对于其他需氧化合物,它优先杀死缺氧肿瘤细胞。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂
• 参考文献:

  [1]. Keyes SR, Rockwell S, Sartorelli AC. Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res. 1985;45(8):3642-3645.

泊非霉素物理化学性质

• 密度: 1.52g/cm3
• 沸点: 560.9ºC at 760 mmHg
• 分子式: C₁₆H₂₀N₄O₅
• 分子量: 348.35400
• 闪点: 293ºC
• 精确质量: 348.14300
• PSA: 127.96000
• InChIKey: HRHKSTOGXBBQCB-VFWICMBZSA-N
• SMILES: COC12C(COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1CC1C2N1C
• 折射率: 1.672

泊非霉素毒性和生态

泊非霉素靶点实验

查看更多实验

实验名称：in vivo activity against aerobic and hypoxic cells in RIF-1 tumors when administered ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL728896

实验名称：Anti cancer activity was determined as lethal dose 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL740252

实验名称：in vivo activity against aerobic and hypoxic cells in RIF-1 tumors when administered ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL728898

实验名称：in vivo activity against aerobic and hypoxic cells in RIF-1 tumors when administered ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL728897

实验名称：Toxicity in ip dosed ddY mouse bearing mouse S180 cells 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1058335

实验名称：T/C value was measured as tumor volume in the treated versus control mice. 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL728805

实验名称：Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed ... 来源：ChEMBL 靶标：CCRF S-180 External Id：CHEMBL1058336

实验名称：Minimum effective dose that show activity against P-388 murine leukemia cells in CDF1... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722474

实验名称：Therapeutic ratio is expressed as ratio of optimal dose and minimum effective dose 来源：ChEMBL 靶标：N/A External Id：CHEMBL841001

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

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泊非霉素英文别名

• N-methylmitomycin C
• porphiromycin
• Methyl MitoMycin C
• Methylmitomycin
• RegaMycin
• Porfiromycine
• porfiromycin
• 8-Azathioxanthine