4055-39-4

• 常用中文名：丝裂霉素A
• 常用英文名：Mitomycin A
• CAS号：4055-39-4
• 分子式：C₁₆H₁₉N₃O₆
• 分子量：349.34
• 相关类别： 研究领域 癌症
• 发布时间：2018-05-16 08:00:00
• 更新时间：2026-07-15 18:06:10
• Mitomycin A 是细菌的代谢物。Mitomycin A 可降低迁移抑制因子 (MIF) 的产生,可用于癌症研究。

名称

• 中文名: 丝裂霉素A
• 英文名: mitomycin A
• 中文别名: 丝裂霉素杂质B; 丝裂霉素杂质B(丝裂霉素A); ((1AS,8S,8,8BS)-6,8A-二甲氧基-5-甲基-4,7-二氧基-1,1A,2,4,7,8,8A,8B-八氢氮杂环[2',3':3,4]吡咯[1,2-A]吲哚-8-基)氨基甲酸甲酯
• 英文别名: [(1aS,8S,8aR,8bS)-6,8a-Dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2,3,4]pyrrolo[1,2-a]indol-8-yl]methyl Carbamate; ((1aS,8S,8,8bS)-6,8a-dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2,3:3,4]pyrrolo[1,2-a]indol-8-yl)methyl cbamate(WXG00529); mitomycin-A; [(1aS,8S,8,8bS)-6,8a-Dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2,3,4]pyrrolo[1,2-a]indol-8-yl]methyl Cbamate; Mitomycin Impurity B; Mitomycin Impurity B (Mitomycin A); (1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; [(1aS,8S,8,8bS)-6,8a-Dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2,’3’:3,4]pyrrolo[1,2-a]indol-8-yl]methyl Cbamate; (1aS,8S,8,8bS)-8-[[(Aminocbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 8-[[(aminocbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methyl-, (1aS,8S,8,8bS); Mitomycin Impurity 2(Mitomycin Impurity B)(Mitomycin A）

物化性质

• 密度: 1.5g/cm3
• 沸点: 587.4ºC at 760 mmHg
• 熔点: 159-161ºC (dec)
• 分子式: C₁₆H₁₉N₃O₆
• 分子量: 349.34
• 闪点: 309.1ºC
• 精确质量: 349.12700
• PSA: 130.10000
• LogP: 0.00350
• 外观性状: 红色-紫罗兰色晶体
• 蒸汽压: 8.83E-14mmHg at 25°C
• 折射率: 1.638
• 储存条件: 室温

生物活性

• 描述: Mitomycin A 是细菌的代谢物。Mitomycin A 可降低迁移抑制因子 (MIF) 的产生,可用于癌症研究。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. van der Nat JM, et al. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro. Immunobiology. 1986 Aug;172(1-2):120-7.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CN1050000 CAS REGISTRY NUMBER : 4055-39-4 LAST UPDATED : 199706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C16-H19-N3-O6 MOLECULAR WEIGHT : 349.38 WISWESSER LINE NOTATION : T D3 B556 BN EM JV MVTTT&J GO1 H1OVZ KO1 L1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 3 ug/L REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,767,1977

合成路线

132732-87-7 ~0% 4055-39-4 110934-24-2

文献：Kasai; Kono; Ikeda; Yoda; Hirayama Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7296 - 7299

50-07-7 ~81% 4055-39-4

文献：Kanda; Kasai Journal of Organic Chemistry, 1990 , vol. 55, # 8 p. 2515 - 2518

186581-53-3 7041-61-4 ~51% 4055-39-4

文献：Sami, Salah M.; Iyengar, Bhashyam S.; Remers, William A.; Bradner, William T. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 168 - 173

67-56-1 122644-74-0 ~66% 4055-39-4

文献：Arai, Hitoshi; Kasai, Masaji Journal of Organic Chemistry, 1993 , vol. 58, # 15 p. 4151 - 4152

7041-61-4 20667-76-9 ~48% 4055-39-4

文献：Vyas; Benigni; Partyka; Doyle Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4307 - 4309

20667-76-9 50-07-7 ~% 4055-39-4

文献：Subramaniam; Kohn Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 10519 - 10526

132732-87-7 ~% 4055-39-4

文献：Kasai; Kono; Ikeda; Yoda; Hirayama Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7296 - 7299

124-41-4 128583-70-0 ~58% 4055-39-4

文献：Furuhata; Komiyama; Takeda; Takayanagi; Torii; Mishima; Ogura; Hata Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2651 - 2654

上下游产品

上游产品  7
132732-87-7 50-07-7 186581-53-3 7041-61-4
67-56-1 122644-74-0 124-41-4
下游产品  10
105139-98-8 801-52-5 15973-07-6 134136-38-2
14896-01-6 118598-87-1 118598-79-1 118598-93-9
7041-61-4 78142-77-5