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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：链黑霉素
纯度：95.0%
规格：
联系人：徐经理
联系电话：13311869306

上海吉至生化科技有限公司
上海市上海市奉贤区
产品名：链黑霉素
纯度：98.0%
规格：5mg/1mg
联系人：刘佳
联系电话：18116092098

上海源溪生物科技有限公司
上海市上海市浦东新区
产品名：Streptonigrin
纯度：98.9%
规格：1g
联系人：赖经理
联系电话：13564518121

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Streptonigrin
纯度：98.0%
规格：1mg/5mg/1g/1g
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：链黑霉素
纯度：95.0%
规格：1mg/1g/1g/1g
联系人：阿拉丁
联系电话：400-620-6333

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]链黑霉素,98%
纯度：98.0%
规格：1mg
联系人：夏言
联系电话：18016376636

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3930-19-6生产厂家

3930-19-6价格

3930-19-6

3930-19-6结构式

常用中文名：棕霉素
常用英文名：bruneomycin
CAS号：3930-19-6
分子式：C₂₅H₂₂N₄O₈
分子量：506.46400
相关类别：原料药抗肿瘤药抗生素类抗肿瘤药
发布时间：2018-09-21 12:50:47
更新时间：2024-01-05 14:37:11
Streptonigrin (Bruneomycin) 是由链霉菌 (Streptomyces flocculus) 产生的一种天然产物,具有抗肿瘤和抗菌活性。Streptonigrin 可作为 pan-PAD 抑制剂,抑制 PAD1,PAD2,PAD3 和 PAD4 的 IC50 分别为 48.3±34.2 μM,26.1±0.3 μM,0.43±0.03 μM 和 2.5±0.4 μM。

化源商城直购

中文名	链黑霉素
英文名	streptonigrin
中文别名	棕霉素
英文别名	Rufocromomycinum Valacidin Rufocromomycine Bruneomycin Streptonigran (4Z)-5-amino-6-(7-amino-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(4,5-dimethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)-3-methyl-1H-pyridine-2-carboxylic acid Nigrin Rufocromomicina Rufocromomycin

描述	Streptonigrin (Bruneomycin) 是由链霉菌 (Streptomyces flocculus) 产生的一种天然产物,具有抗肿瘤和抗菌活性。Streptonigrin 可作为 pan-PAD 抑制剂,抑制 PAD1,PAD2,PAD3 和 PAD4 的 IC50 分别为 48.3±34.2 μM,26.1±0.3 μM,0.43±0.03 μM 和 2.5±0.4 μM。
相关类别	研究领域 >> 癌症研究领域 >> 感染信号通路 >> 表观遗传学 >> 蛋白质精氨酸脱亚胺酶
靶点	Anti-bacterial[1] IC50: 48.3±34.2 µM (PAD1), 26.1±0.3 µM, (PAD2), 0.43±0.03 µM (PAD3), 2.5±0.4 µM (PAD4)[1]
参考文献	[1]. Dreyton CJ, et al. Insights into the mechanism of Streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.

密度	1.54g/cm3
沸点	719ºC at 760mmHg
熔点	301-303℃
分子式	C₂₅H₂₂N₄O₈
分子量	506.46400
闪点	388.7ºC
精确质量	506.14400
PSA	197.18000
LogP	3.59940
折射率	1.716
储存条件	2-8°C
计算化学	1.疏水参数计算参考值（XlogP）:0.5 2.氢键供体数量:4 3.氢键受体数量:12 4.可旋转化学键数量:5 5.互变异构体数量:645 6.拓扑分子极性表面积:193 7.重原子数量:37 8.表面电荷:0 9.复杂度:1310 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:1 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ7350000

CHEMICAL NAME :: Picolinic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2- quinolyl)-4-(2- hydroxy-3,4-dimethoxyphenyl)-3-methyl-

CAS REGISTRY NUMBER :: 3930-19-6

BEILSTEIN REFERENCE NO. :: 0599390

LAST UPDATED :: 199806

DATA ITEMS CITED :: 64

MOLECULAR FORMULA :: C25-H22-N4-O8

MOLECULAR WEIGHT :: 506.51

WISWESSER LINE NOTATION :: T66 BV EV GNJ CO1 DZ H- BT6NJ CZ DR BQ CO1 DO1& E1 FVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 ug/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2330 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 520 ug/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 865 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Blood - leukopenia Blood - changes in platelet count

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 600 ug/kg

TOXIC EFFECTS :: Blood - leukopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg/10D-I

TOXIC EFFECTS :: Blood - other changes Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1710 ug/kg/7D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume decreased

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 ug/kg/10D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 250 ug/kg/10D-I

TOXIC EFFECTS :: Blood - leukopenia Blood - changes in bone marrow (not otherwise specified) Blood - changes in platelet count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 ug/kg/10D-I

TOXIC EFFECTS :: Blood - leukopenia Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 ug/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 ug/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 ug/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 250 ug/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 100 ug/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 100 ug/kg

SEX/DURATION :: female 2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 90 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TEST SYSTEM :: Rodent - rabbit

DOSE/DURATION :: 30 ug/kg

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl 3),48,1985 *** REVIEWS *** TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

符号	GHS06
信号词	Danger
危害声明	H300
警示性声明	P264-P301 + P310
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T+: Very toxic;
风险声明 (欧洲)	28
安全声明 (欧洲)	53-28-36/37/39-45
危险品运输编码	UN 3462 6.1/PG 1
WGK德国	3
RTECS号	TJ7350000
包装等级	II
危险类别	6.1(a)