63428-13-7

• 常用中文名：酒石酸乙酰异戊酰泰乐菌素
• 常用英文名：Tylvalosin tartrate
• CAS号：63428-13-7
• 分子式：C₅₇H₉₃NO₂₅
• 分子量：1192.340
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-02-28 08:00:00
• 更新时间：2024-01-04 23:14:44
• Tylvalosin tartrate (Acetylisovaleryltylosin tartrate) 是一种大环内酯类抗生素,对革兰氏阳性细菌具有抗性 (Gram-positive bacteria)。

名称

• 中文名: 酒石酸乙酰异戊酰泰乐菌素
• 英文名: Acetylisovaleryltylosin tartrate
• 中文别名: 泰万菌素
• 英文别名: (2R,3R)-2,3-Dihydroxysuccinic acid - [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[4-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3,6-dideoxy-3-(dimethylamino)-α-D-glucopyranosyl]oxy} -2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-4-O-(3-methylbutanoyl)-β-D-allopyranoside (1:1); Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[[4-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3,6-dideoxy-3-(dimethylamino)-α-D-gl ucopyranosyl]oxy]-15-[[[6-deoxy-2,3-di-O-methyl-4-O-(3-methyl-1-oxobutyl)-β-D-allopyranosyl]oxy]methyl]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-diene-7-acetaldehyde (1: 1)

物化性质

• 分子式: C₅₇H₉₃NO₂₅
• 分子量: 1192.340
• 精确质量: 1191.603638
• PSA: 365.87000
• LogP: 1.87870
• 储存条件: 室温，干燥，密封

生物活性

• 描述: Tylvalosin tartrate (Acetylisovaleryltylosin tartrate) 是一种大环内酯类抗生素,对革兰氏阳性细菌具有抗性 (Gram-positive bacteria)。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Feng-yu Deng, et al. Characterization of the Interaction between Acetylisovaleryltylosin Tartrat and Bovine Serum Albumin without or with Zn2+ and Cu2+ by Spectroscopic Analysis. Guang Pu Xue Yu Guang Pu Fen Xi. 2016 Jul;36(7):2351-7.

  [2]. R Okamoto, et al. The activity of 4''-acylated tylosin derivatives against macrolide-resistant gram-positive bacteria. J Antibiot (Tokyo). 1979 May;32(5):542-4.

安全

• 危害码 (欧洲): Xi