104713-75-9

• 常用中文名：(4S)-2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二羧酸 (3S)-1-苄基-3-吡咯烷基-甲基酯
• 常用英文名：Barnidipine
• CAS号：104713-75-9
• 分子式：C₂₇H₂₉N₃O₆
• 分子量：491.536
• 相关类别： 原料药 循环系统用药 防治心绞痛药
• 发布时间：2018-03-30 08:00:00
• 更新时间：2026-07-04 19:02:47
• Barnidipine (Mepirodipine) 巴尼地平是一种 L 型钙拮抗剂 (CaA),对 [3H] initrendipine 结合位点具有高亲和力 (Ki=0.21 nmol/l),对 CaA 受体具有选择性作用。Barnidipine (Mepirodipine) 巴尼地平是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。

名称

• 中文名: 巴尼地平
• 英文名: (+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
• 中文别名: 巴尼地平,美洛地平; 尼巴地平 D5; 巴尼地平-D5; 巴尼地平-氘5
• 英文别名: Bnidipine,Inhibitor,Ca2+ channels,Calcium Channel,inhibit,Ca channels; (3S)-1-Benzyl-3-pyrrolidinyl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate; mepirodipine; (4S)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester; (S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; [S-(R*,R*)]-1,4-Dihydro-2,6-di methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 1-(Phenylmethyl)-3-pyrrolidinyl Ester; Bnidipine, 10 mM in DMSO; (S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicboxylate; Bnidipine(b); (+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicboxylate; (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester; YM-09730-5(Free base); Bnidipine //BP; (3S)-1-Benzylpyrrolidin-3-yl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Bnidipine-d5; BNIDIPINE; (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester; (3S)-1-benzyl-3-pyrrolidinyl methyl (4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicboxylic acid 3-methyl 5-[(3S)-1-benzylpyrrolidin-3β-yl] ester; 3,5-Pyridinedicboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, (4S); (S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3; (S)-3-((S)-1-Benzylpyrrolidin-3-yl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridin; Hypoca; (4S)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 614.5±55.0 °C at 760 mmHg
• 熔点: 137-139°
• 分子式: C₂₇H₂₉N₃O₆
• 分子量: 491.536
• 闪点: 325.4±31.5 °C
• 精确质量: 491.205627
• PSA: 113.69000
• LogP: 4.36
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.628
• 储存条件: -20°C

生物活性

• 描述: Barnidipine (Mepirodipine) 巴尼地平是一种 L 型钙拮抗剂 (CaA),对 [3H] initrendipine 结合位点具有高亲和力 (Ki=0.21 nmol/l),对 CaA 受体具有选择性作用。Barnidipine (Mepirodipine) 巴尼地平是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 靶点:

  Ki: 0.21 nmol/l ([3H] initrendipine)[1]

• 参考文献:

  [1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8

  [2]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.

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