832714-46-2

• 常用中文名：APD668
• 常用英文名：APD 668
• CAS号：832714-46-2
• 分子式：C₂₁H₂₄FN₅O₅S
• 分子量：477.509
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 GPR119
• 发布时间：2016-12-15 12:36:02
• 更新时间：2026-06-30 11:00:48
• APD668是GPR119激动剂,对人GPR119和大鼠GPR119的EC50分别为2.7 nM和33 nM。

名称

• 中文名: APD668
• 英文名: Isopropyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3 ,4-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate
• 中文别名: 4-((1-(2-氟-4-(甲基磺酰基)苯基)-1H-吡唑并[3,4-D]嘧啶-4-基)氧基)哌啶-1-甲酸异丙酯; 4-(1-(2-氟-4-(甲磺酰基)苯基)-1H-吡唑并[3,4-D]嘧啶-4-氧基)哌啶-1-羧酸异丙酯; APD668试剂; 异丙基 4-(1-(2-氟-4-(甲基磺酰基)苯基)-1H-吡唑并[3,4-D]嘧啶-4-基氧基)哌啶-1-羧酸
• 英文别名: APD668 ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CBOXYLATE; APD 668; APD-668; isopropyl 4-(1-(2-fluorine-4-(cbosulfonyl)phenyl)-1H-pyrazolo[3,4-D]pyrimidine-4-oxy)piperidine-1-cboxylate; APD668; isopropyl 4-((1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)piperidine-1-cboxylate APD668; Inhibitor,CYPs,APD668,diabetes,Cytochrome P450,APD-668,GPR119,Potassium Channel,coupled,G-protein,steatohatitis,CYP2C9,G Protein-Coupled Rector 119,inhibit,KcsA; 4-[[1-(2-Fluoro-4-methylsulfonylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]piperidine-1-cboxylic acid isopropyl ester; APD668, 10 mM in DMSO; APD 668, >=; 1-Piperidinecboxylic acid,4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester; Isopropyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate; 1-Piperidinecarboxylic acid, 4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 611.6±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄FN₅O₅S
• 分子量: 477.509
• 闪点: 323.7±31.5 °C
• 精确质量: 477.148224
• PSA: 124.89000
• LogP: 1.99
• 外观性状: white solid
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.658
• 储存条件: -20℃

生物活性

• 描述: APD668是GPR119激动剂,对人GPR119和大鼠GPR119的EC50分别为2.7 nM和33 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR119
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Semple G, et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41.