71184-20-8

• 常用中文名：Carbodine
• 常用英文名：Carbodine
• CAS号：71184-20-8
• 分子式：C₁₀H₁₅N₃O₄
• 分子量：286.38700
• 相关类别： 信号通路 抗感染 流感病毒
• 发布时间：2017-01-18 00:18:56
• 更新时间：2026-07-15 17:04:14
• Carbodine (Carbocyclic cytidine) 是一种广谱抗病毒药物,对 DNA 病毒、(+)RNA 病毒、(-)RNA 病毒、paramyxo, rhabdo 和 (+/-)RNA 病毒均有活性,靶向将 UTP 转换为 CTP 的 CTP 合成酶。Carbodine (Carbocyclic cytidine) 在体外具有显著的抗流感病毒 A0/PR-8/34 和 A2/Aichi/2/68 活性。

名称

• 英文名: 2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)benzenesulfonic acid
• 英文别名: 4-Amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-2(1H)-pyrimidinone; p-Isooctylphenol-2-sulfonic acid; C-Cyd; (-)-carbodine; 2-Hydroxy-5-(1,1,3,3-tetramethylbutyl)benzenesulfonic acid; Benzenesulfonic acid,2-hydroxy-5-(1,1,3,3-tetramethylbutyl); Cbodine; 4-Amino-1-[(1R)-2α,3α-dihydroxy-4β-(hydroxymethyl)cyclopentan-1β-yl]-2(1H)-pyrimidinone; D-(-)-carbodine; Cbodine (Cbocyclic cytidine); 2(1H)-Pyrimidinone, 4-amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]; (1R,2S,3R,4R)-1-[2,3-dihydroxy-4-(hydroxymethyl)-cyclopentan-1-yl]cytosine

物化性质

• 密度: 1.74g/cm3
• 沸点: 477ºC at 760 mmHg
• 分子式: C₁₀H₁₅N₃O₄
• 分子量: 286.38700
• 闪点: 242.3ºC
• 精确质量: 286.12400
• PSA: 82.98000
• LogP: 4.43350
• 折射率: 1.743

生物活性

• 描述: Carbodine (Carbocyclic cytidine) 是一种广谱抗病毒药物,对 DNA 病毒、(+)RNA 病毒、(-)RNA 病毒、paramyxo, rhabdo 和 (+/-)RNA 病毒均有活性,靶向将 UTP 转换为 CTP 的 CTP 合成酶。Carbodine (Carbocyclic cytidine) 在体外具有显著的抗流感病毒 A0/PR-8/34 和 A2/Aichi/2/68 活性。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 参考文献:

  [1]. De Clercq E, et al. Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine. Biochem Pharmacol. 1990 Jan 15;39(2):319-25.

  [2]. Shannon WM, et al. Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses. Antimicrob Agents Chemother. 1981 Dec;20(6):769-76.

合成路线

1070967-50-8 ~81% 71184-20-8

文献：Rao, Jagadeeshwar R.; Jha, Ashok K.; Rawal, Ravindra K.; Sharon, Ashoke; Day, Craig W.; Barnard, Dale L.; Smee, Donald F.; Chu, Chung K. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2601 - 2604

188118-73-2 ~96% 71184-20-8

文献：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Chemical Communications, 1996 , # 14 p. 1623 - 1624

143395-28-2 ~% 71184-20-8

文献：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250

160154-62-1 ~% 71184-20-8

文献：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250

178456-34-3 ~% 71184-20-8

文献：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250

188118-61-8 ~% 71184-20-8

文献：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250

216441-13-3 ~% 71184-20-8

文献：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Chemical Communications, 1996 , # 14 p. 1623 - 1624

148473-12-5 ~% 71184-20-8

文献：Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Chemical Communications, 1996 , # 14 p. 1623 - 1624

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