132335-47-8

• 常用中文名：二甲基草酸盐
• 常用英文名：S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
• CAS号：132335-47-8
• 分子式：C₂₁H₂₃NO₅S
• 分子量：401.476
• 发布时间：2018-12-28 20:34:31
• 更新时间：2026-07-11 15:06:24
• 【用途一】
  (S)-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺草酸盐
  【132335-47-8】
  是生产对5-羟色胺和去甲肾上腺素的再吸收有双重抑制作用的抗抑郁药药物度洛西汀的中间体。

名称

• 中文名: (S)-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺草酸盐
• 英文名: (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate
• 中文别名: S-(+)-N,N-二甲基-3-(1-萘氧基)-3-(2-噻吩)丙胺草酸盐; (S)-N,N-二甲基-3-(萘-1-基氧基)-3-(噻吩-2-基)丙-1-胺草酸盐; 度洛西汀杂质 52; N-甲基草酸度洛西汀; S-(+)-N,N-二甲基-3-(1-奈氧基-3-(2-噻吩基)-丙胺磷酸盐; S-(+)-N,N-二甲基-3 - (1 - 萘氧基)-3 - (2 - 噻吩基)-1 - 丙胺草酸盐; (S)-(+)-N,N-二甲基-3-(1-蓁氧基)-3-(2-噻吩基)丙胺草酸盐; N-甲基度洛西汀草酸盐; 度洛西汀N-甲基草酸; 度洛西汀中间体草酸盐; 度洛西汀杂质8草酸盐; 盐酸度洛西汀杂质19; 度洛西汀N-草酸甲酯
• 英文别名: Duloxetine N-methyl Impurity; S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S); (S)-(+)-N,N-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thinyl)Propanamine Oxalate; (3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine Oxalate); N-Methyl Duloxetine Oxalate; (S)-(+)-N,N-dimethyl-3-(1-naphthloxy)-3-(2-thienyl)prpylamine oxalate; (3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine; S-(+)-N1N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINE OXALATE; (S)-N,N-DiMethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine oxalate; Duloxetine N-Methyl Oxalate; S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-propylamine Oxalate; Duloxetine intermediate; (S)-N,N-Dimethyl-g-(1-naphthalenyloxy)-2-thiophenropanamine ethanedioate (1:1); (S)-(+)-N,N-DIMETHYL-3-NAPTHTOXY-(2-THIOPHENE) PROPYLAMINE OXALATE; 2-Thiophenropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, eth; (S)-(+)-N,N-DIMETHYL-3-(1-NAPTHTALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINEHYDROCHLORIDE; (3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate; 2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, (γS)-, ethanedioate (1:1); s-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate; 2-Thiophenropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, ethanedioate (1:1), (γS); S(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamineoxalate; S-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANEMAINEOXALATE; (S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIENYL)-PROPANAMINE OXALATE, DULOXETIN INTERMEDIATE; S-(+)-N,N-Dimethyl-3-(1-phthoxy)-3-(2-thienyl)-1-propylamine oxalate; S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory; Duloxetine N-Methyl (S)-Isomer Oxalate; Duloxetine Impurity 8 Oxalate; (3S)-N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine ethanedioate (1:1); (3S)-N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine ethanedioate (1:1); (S)-(+)-N,N-diMethyl-3-(naphthloxy)-3-(2-thienyl); S-(+)-N,N-dimethtl-3-(1-naphthoxy)-3-(2-thienyl)-1-propanamine oxalate; T5SJ BY2N1&1&O- BL66J &&S Form oxalate; (S)-N,N-DiMethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanaMine Ethanedioate; Duloxetine Impurity 52; (S)-(+) N,N-dimethyl-3-(1-napthalenyloxy)-3-(2_thieyl)prapanamine oxalate; (S)-(+)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-propanamine oxalate; S-(+)-N,N-Dimethyl-3-(1-naphtho; Duloxetine Impurity 8(Oxalicacid); N,N-dimethyl-3-(1-naphthalenyloxy)-3-thiophen-2-yl-1-propanamine; (S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIOPHENE)-PROPYLAMINE OXALATE

物化性质

• 密度: 1.146 g/cm3
• 沸点: 459.744ºC at 760 mmHg
• 分子式: C₂₁H₂₃NO₅S
• 分子量: 401.476
• 闪点: 231.845ºC
• 精确质量: 401.129700
• PSA: 115.31000
• LogP: 4.12870
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.624
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

合成路线

321-38-0 144-62-7 132335-44-5 ~61% 132335-47-8

文献：Suthrapu, Sashikanth; Sripathi, Somaiah; Veeramalla, Raju; Bojja, Ramachandra Reddy; Karnati, Venugopal Reddy Organic Process Research and Development, 2009 , vol. 13, # 5 p. 854 - 856

144-62-7 132335-46-7 ~82% 132335-47-8

文献：Medichem S.A. Patent: US2009/93645 A1, 2009 ; Location in patent: Page/Page column 6 ;

13636-02-7 321-38-0 144-62-7 ~% 132335-47-8

文献：WO2011/33366 A2, ; Page/Page column 23 ;

321-38-0 ~81% 132335-47-8

文献：KRKA, D.D., Novo Mesto Patent: EP2133072 A1, 2009 ;

144-62-7 116817-11-9 ~% 932013-45-1 132335-47-8

文献：WO2007/38253 A2, ; Page/Page column 19 ;

144-62-7 878757-08-5 132335-46-7 ~% 932013-45-1 详细

文献：WO2007/86948 A1, ; Page/Page column 15 ;

5424-47-5 ~% 132335-47-8

文献：Tetrahedron Letters, , vol. 31, # 45 p. 7101 - 7104

88-15-3 ~% 132335-47-8

文献：Tetrahedron Letters, , vol. 31, # 45 p. 7101 - 7104

321-38-0 132335-44-5 ~% 132335-47-8

文献：Tetrahedron Letters, , vol. 31, # 45 p. 7101 - 7104

上下游产品

上游产品  9
321-38-0 144-62-7 132335-44-5 132335-46-7
13636-02-7 116817-11-9 878757-08-5 5424-47-5
88-15-3
下游产品  2
132335-46-7 136434-34-9

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%