毒理学数据:
主要的刺激性影响：
在皮肤上面：刺激皮肤和粘膜
在眼睛上面：刺激的影响
致敏作用：没有已知的敏化现象
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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MD6475000
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CHEMICAL NAME :
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Gold, (1-thio-D-glucopyranosato)-
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CAS REGISTRY NUMBER :
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12192-57-3
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LAST UPDATED :
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199606
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DATA ITEMS CITED :
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19
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MOLECULAR FORMULA :
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C6-H11-O5-S.Au
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MOLECULAR WEIGHT :
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392.20
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WISWESSER LINE NOTATION :
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T6OTJ BS-AU-H CQ DQ EQ F1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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5500 ug/kg/10W-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - cough Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature increase
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REFERENCE :
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SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 88,644,1995
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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2600 ug/kg/15D-I
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting Liver - other changes
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REFERENCE :
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ARHEAW Arthritis and Rheumatism. (Arthritis Foundation, 1314 Spring St., NW, Atlanta, GA 30309) V.1- 1958- Volume(issue)/page/year: 27,230,1984
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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3357 ug/kg/4W-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - effect, not otherwise specified
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REFERENCE :
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JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 12,619,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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2700 ug/kg/4W-I
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TOXIC EFFECTS :
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Liver - jaundice, cholestatic
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REFERENCE :
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JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 11,843,1984
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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3 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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SAVEAB Sammlung von Vergiftungsfaellen. (Berlin, Germany) V.1-13, 1930-44; V.14, 1952-54. For publisher information, see ARTODN. Volume(issue)/page/year: 10,101A,1939
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2 gm/kg
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TOXIC EFFECTS :
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Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
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REFERENCE :
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PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 70,498,1949
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1650 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71. Suspended. Volume(issue)/page/year: 3,146,1945
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Bird - chicken
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DOSE/DURATION :
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1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921- Volume(issue)/page/year: 52,926,1973
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Bird - chicken
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DOSE/DURATION :
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300 mg/kg
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 35,223,1976 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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400 mg/kg
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
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REFERENCE :
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PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 3,37,1959
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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750 mg/kg
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Musculoskeletal - tumors
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REFERENCE :
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RFECAC Revue Francaise d'Etudes Cliniques et Biologiques. (Paris, France) V.1-14, 1956-69. For publisher information, see BIMDB3. Volume(issue)/page/year: 13,40,1968
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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750 mg/kg
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors
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REFERENCE :
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RFECAC Revue Francaise d'Etudes Cliniques et Biologiques. (Paris, France) V.1-14, 1956-69. For publisher information, see BIMDB3. Volume(issue)/page/year: 11,828,1966 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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400 mg/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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REFERENCE :
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PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 124,1190,1967
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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DOSE :
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800 mg/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina
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REFERENCE :
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ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 78,845,1966 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,39,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,39,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 13(1),209,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1852 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 7622 (estimated) No. of Female Employees: 7177 (estimated)
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