88150-62-3

• 常用中文名：邻苯二甲酰基氨氯地平
• 常用英文名：Amlodipine intermediate
• CAS号：88150-62-3
• 分子式：C₂₈H₂₇ClN₂O₇
• 分子量：538.976
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-03-24 08:00:00
• 更新时间：2026-07-09 18:47:26
• Phthalimidoamlodipine is an impurity of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.

名称

• 中文名: 邻苯二甲酰基氨氯地平
• 英文名: Phthaloyl amlodipine
• 中文别名: 马来酸氨氯地平中间体; 苯磺酸氨氯地平杂质A 标准品; 安氯地平中间体; 阿莫地平杂质A; 氨氯地平杂质; 邻苯二甲酰基氨氯地平(氨氯地平亚胺); 氨氯地平及其中间体; 邻苯二甲酰胺氨氯地平; 邻苯二酚氨氯地平(氨氯地平中间体); 邻苯二甲酰基氨氯地平(氨氯地平杂质); 氨氯地平杂质A命名); 氨氯地平亚胺-40; 氨氯地平杂质A:氨氯地平杂质A; 邻苯二甲酰亚胺氨氯地平; 氨氯地平亚胺; 4-(2-氯苯基)-2-(((2-(1,3-二氧代异吲哚啉-2-基)乙氧基)甲基)-6-甲基-1,4-二氢吡啶-3-羧酸乙酯-5-羧酸甲酯; 4-(2-氯苯基)-3-乙氧羰基-5-甲氧羰基-6-甲基-2-(酞酰亚氨基乙氧基)甲基-1,4-二氢吡啶; 氨氯地平杂质A; 阿洛地平杂质A; 氨氯地平A; 氨氯地平相关化合物D; 氨氯地平杂质A-F; 4-(2-氯苯基)-2-(((2-(1,3-二氧代异吲哚啉-2-基)乙氧基)甲基)-6-甲基-1,4-二氢吡啶-3-羧酸乙酯-5-羧酸甲酯(邻苯二甲酰基氨氯地平); 苯磺酸氨氯地平杂质A对照品; 邻苯二甲酰氨氯地平; 氨氯地平杂质1(氨氯地平杂质A)
• 英文别名: 4-(2-Chlorophenyl)-3-(ethoxycbonyl)-5-(Methoxycbonyl)-6-Methyl-2-[(2-phthal; 4-(2-chlorophenyl)-2-[2-(1,3-dioxo-2-isoindolyl)ethoxymethyl]-3-ethyl-5,6-dimethylpiperidine-3,5-dicboxylate; Amlodipine Impurity A：Amlodipine Impurity A; Amlodipine-1; 3-ETHYL-5-METHYL-4-(2-CHLOROPHENYL)-2-(2-PHTHALIMIDOETHOXY)METHYL-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICBOXYLATE; Amlodipine Impurity-A /Amlodipine Related Compound D (Phthaloyl Amlodipine); Amlodipine impurities1740; PHTHALOYL AMLODIPINE; 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2-phthalimidoethoxyl)methyl-6-methyl-1,4-dihydropyridine-3,5-dicboxylate; 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicboxylate; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl}-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate; 3-ethyl 5-methyl 4-(2-chlorophenyl); 3-Ethyl-5-Methyl-4-(2-Chlorophenyl)-2-(2-Phthalimidoethoxy)Methyl-6-Methyl-1,4-Dihydro-Pyridine-3,5-Didboxylate; Amlodipine Imp A; 3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl]-6-methyl-1,4-dihyd; EINECS 413-410-3; T56 BVNVJ C2O1- BT6M DHJ CVO2 DR BG& EVO1 F1; Amlodipine Phthalimide; Amlodipine besilate impurity A; 3-Ethyl 5-Methyl (4RS)-4-(2-Chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methy; AMLODIPINE INTERMEDIATE; 3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1; 3-Ethyl-5-methyl-4-(2-Chlorophenyl)-2-(2-phthalimidoethoxl)-methyl-6-methyl-1,4-dihydropyridine-3,5-Dicboxylate; 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]methyl]-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; Amlodipine Related Compound D (F012S0); MFCD07782096; Amlodipine Related Compound D/Amlodipine Impurity A; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methyl-1; 4-(2-Chlorophenyl)-3-ethoxycbonyl-5-methoxycbonyl- 6-methyl-2-(phthalimidoethoxy)methyl-1,4- dihydropyridine (Phthaloyl Amlodipine); 4-(2-Chlorophenyl)-3-ethoxycbonyl-5-methoxycbonyl-6-methyl-2-(phthalimidoethoxy)methyl-1,4-dihydropyridine; 4-(2-Chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-3,5-pyridinedicboxylic Acid 3-Ethyl 5-Methyl Ester; Amlodipine imine; Amlodipine Related Compound D; Phthaloyl amlodipine (p-3) of RS-amlodipine besylate; AMlodipine IMpurity A; 3-Ethyl 5-Methyl (4RS)-4-(2-Chlorop; Phthaloyl Amlodipine (Amlodipine intermediate); Amlodipine Related Compound D (3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-{[2-(1,3-dioxoisoindolin-2-yl); 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicboxylate; Phthalimidoamlodipine; 3-Ethyl-5-Methyl (4RS)-4-(2-Chloroenyl)-2-[[2-(1,3-dioxo- 1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicboxylate; 4-(2-Chlorophenyl)-3-Ethoxy carbonyl-5-Methoxy cbonil-6-Methyl-2-(phthaliMidoethoxy)Methyl-1,4-dihydropyridine; AMlodipine IMpurity-A; 1-Amino-6-fluoro-1,4-dihydro-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxo-[1,3]thiazeto[3,2-A]quinoline-3-cboxylic acid; Amlodipine impurity A Amlodipine RC D,Phthaloyl Amlodipine; 3,5-Pyridinedicboxylicacid,4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-,3-ethyl 5-Methyl ester; Amlodipine Impurity 1; AMLODIPINE PHTHALOYL / BASE; PHTHALIMIDO AMLODIPINE IMPURITY -A/RC-D; Amlodipine Impurity A (Amlodipine Related Compound D); Phthaloylamlodipine (Amlodipine Impurity); 3-O-ethyl 5-O-methyl 4-(2-chlorophenyl)-2-[2-(1,3-dioxoisoindol-2-yl)ethoxymethyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-ethyl 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-2-[2-(1,3-dihydro-1,3-dioxo-(2H)isoindol-2-yl)-ethoxymethyl]-6-methyl-3,5-pyridinedicboxylate; Amlodipine Impurity AQ: What is Amlodipine Impurity A Q: What is the CAS Number of Amlodipine Impurity A Q: What is the storage condition of Amlodipine Impurity A Q: What e the applications of Amlodipine Impurity A; Amlodipine Impurity 1（Amlodipine Impurity A）

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 654.1±55.0 °C at 760 mmHg
• 熔点: 140-145ºC
• 分子式: C₂₈H₂₇ClN₂O₇
• 分子量: 538.976
• 闪点: 349.4±31.5 °C
• 精确质量: 538.150696
• PSA: 111.24000
• LogP: 6.38
• 外观性状: 固体;White to Orange to Green powder to crystal
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.589
• 储存条件: Refrigerator

安全

• 风险声明 (欧洲): R53
• 安全声明 (欧洲): 61
• 危险品运输编码: NONH for all modes of transport

合成路线

89-98-5 21731-17-9 88150-75-8 ~32% 88150-62-3

文献：MATRIX LABORATORIES LTD Patent: WO2006/3672 A1, 2006 ; Location in patent: Page/Page column 6; 7 ;

3891-07-4 ~% 88150-62-3

文献：Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

638-07-3 ~% 88150-62-3

文献：Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

89-98-5 14205-39-1 88150-75-8 ~24% 88150-62-3

文献：Arrowsmith; Campbell; Cross; Stubbs; Burges; Gardiner; Blackburn Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1696 - 1702

上下游产品

上游产品  6
89-98-5 21731-17-9 88150-75-8 3891-07-4
638-07-3 14205-39-1
下游产品  4
88150-47-4 88150-42-9 111470-99-6 721958-72-1