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56-94-0

56-94-0结构式

常用中文名：地美溴铵
常用英文名：Demecarium bromide
CAS号：56-94-0
分子式：C₃₂H₅₂Br₂N₄O₄
分子量：716.588
相关类别：原料药神经系统用药拟胆碱药
发布时间：2018-07-04 22:24:42
更新时间：2024-01-05 10:02:46
Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。

中文名	地美溴铵
英文名	demecarium bromide
中文别名	3,3'-(1,10-亚癸基双((甲基亚氨)甲酰氧基))双(N,N,N-三甲基苯铵))二溴化物地美溴胺待买卡农
英文别名	Tosmilen 3,3'-{1,10-Decanediylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide Visumiotic Demekastigmine bromide 3,3'-{Decane-1,10-diylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide Tonilen trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium,dibromide 3,3'-[1,10-Decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethylbenzenaminium]dibromide Benzenaminium, 3,3'-[1,10-decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethyl-, bromide (1:2) Humorsol Tosmicil decamethylenebis[m-dimethylaminophenyl n-methylcarbamate] dimethobromide Decamethylenebis[N-methylcarbamic Acid m-Dimethylaminophenyl Ester] Bromidethylate Tosmilene EINECS 200-301-9 Demecarium bromide N,N'-Bis[3-trimethylammoniumphenoxycarbonyl]-N,N'-dimethyldecamethylenediamine Dibromide Frumtosnil Visumatic

描述	Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。
相关类别	研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> 疼痛
靶点	Kiapp: 0.15 μM (Cholinesterase)[1]
体内研究	去甲肾上腺素(0.125和0.5％)引起长期瞳孔缩小,降低了正常血压眼和遗传性青光眼的小于眼内压(IOP)[1]。
参考文献	[1]. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223(1):20-4. [2]. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93.

熔点	164 - 170ºC
分子式	C₃₂H₅₂Br₂N₄O₄
分子量	716.588
精确质量	714.235535
PSA	59.08000
LogP	0.77020
储存条件	2-8℃
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:6 4.可旋转化学键数量:17 5.互变异构体数量:无 6.拓扑分子极性表面积59.1 7.重原子数量:42 8.表面电荷:0 9.复杂度:686 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:3

CHEMICAL NAME :: Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate)

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,307,1960

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3186 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 3239 (estimated) No. of Female Employees: 1168 (estimated)