7636-26-2

• 常用中文名：2-氨基-3-(4-羟基-3-甲氧基苯基)丙酸
• 常用英文名：(DL)-3-O-Methyldopa
• CAS号：7636-26-2
• 分子式：C₁₀H₁₃NO₄
• 分子量：211.214
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-12-24 22:08:18
• 更新时间：2024-01-01 19:00:23
• 3-O-甲基-DL-DOPA是一种存在于脑脊液中的内源性代谢产物,可用于研究癫痫、嘌呤核苷磷酸化酶缺乏症和芳香L氨基酸脱羧酶缺乏症[1][2][3][4]。

名称

• 中文名: 2-氨基-3-(4-羟基-3-甲氧基苯基)丙酸
• 英文名: 2-Amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid
• 中文别名: 3-甲氧基酪氨酸; 3-O-甲基多巴; 3-(4-羟基-3-甲氧基苯基)丙氨酸
• 英文别名: 3-Methoxytyrosine; 3-Methoxy-D,L-tyrosine; 2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid; 3-Methoxy-tyrosine; Tyrosine, 3-methoxy-; 3-METHOXY-DL-TYROSINE; UNII:SO86T1OB2P; 3-O-Methyldopa

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 407.3±45.0 °C at 760 mmHg
• 分子式: C₁₀H₁₃NO₄
• 分子量: 211.214
• 闪点: 200.1±28.7 °C
• 精确质量: 211.084457
• PSA: 92.78000
• LogP: 0.08
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.591
• 储存条件: 室温，密闭，干燥

生物活性

• 描述: 3-O-甲基-DL-DOPA是一种存在于脑脊液中的内源性代谢产物,可用于研究癫痫、嘌呤核苷磷酸化酶缺乏症和芳香L氨基酸脱羧酶缺乏症[1][2][3][4]。
• 相关类别:
  研究领域 >> 神经疾病
• 体外研究: 内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。
• 参考文献:

  [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

  [2]. Darin N, et al. Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy. Am J Hum Genet. 2016 Dec 1;99(6):1325-1337.

  [3]. Ormazabal A, et al. Pyridoxal 5'-phosphate values in cerebrospinal fluid: reference values and diagnosis of PNPO deficiency in paediatric patients. Mol Genet Metab. 2008 Jun;94(2):173-7.

  [4]. Abdenur JE, et al. Aromatic l-aminoacid decarboxylase deficiency: unusual neonatal presentation and additional findings in organic acid analysis. Mol Genet Metab. 2006 Jan;87(1):48-53.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: 3-Methoxy-DL-tyrosine Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:3-Methoxy-DL-tyrosine CAS number:7636-26-2 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C10H13NO4 Molecular weight:211.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 风险声明 (欧洲): 22-36/37/38
• 安全声明 (欧洲): 22-26-36/37/39
• 危险品运输编码: NONH for all modes of transport

合成路线

6391-59-9 74-90-8 ~% 7636-26-2

文献：Journal of the Chemical Society, , p. 1692,1694

60470-82-8 ~% 7636-26-2

文献：Journal of Organic Chemistry, , vol. 23, p. 27,32

5447-36-9 ~% 7636-26-2

文献：Journal of the Chemical Society, , p. 1795,1799

93-28-7 ~% 7636-26-2

文献：Journal of the Chemical Society, , p. 1692,1694

5438-45-9 ~% 7636-26-2

文献：Journal of the Chemical Society, , p. 1795,1799

62682-19-3 ~% 7636-26-2

文献：Journal of the American Chemical Society, , vol. 35, p. 1611

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