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65928-58-7

65928-58-7结构式

常用中文名：地诺孕素
常用英文名：Dienogest
CAS号：65928-58-7
分子式：C₂₀H₂₅NO₂
分子量：311.418
相关类别：生物化工抑制剂内分泌及激素(Endocrinology & Hormones) Estrogen/progestogen Receptor Chemical
发布时间：2018-06-14 00:47:09
更新时间：2026-07-04 08:52:56
Dienogest(STS-557)是孕酮受体激动剂,有口服的子宫内膜活性,可作用于子宫内膜异位。

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中文名	双烯孕腈
英文名	dienogest
中文别名	地诺孕素(孕酮受体激动剂) Dienogest 10mg试剂诺孕素系统适用性标准品二炔诺酮杂质 17Α-氰甲基-17Β-羟基-13Β-甲基雌甾-4,9-二烯-3-酮地诺孕素杂质 2-((8S,13S,14S,17R)-17-羟基-13-甲基-3-氧代-2,3,6,7,8,11,12,13,14,15,16,17-十二氢-1H-环戊基[A]菲-17-基)乙腈诺孕素标准品地诺允素地诺孕诺 13C,2H3,15N]-地诺孕素地诺孕素(甾体) 地诺孕素,10 MM DMSO 溶液 D198-地诺孕素地诺孕素片 17Α-氰甲基-17Β-羟基-13Β-甲基甾烷-4,9-二烯-3-酮氘6-地屈孕酮地诺孕素 Dienogest
英文别名	DIENOGEST CAS NO.:65-9 BAY-86-5258 17a-Cyanomethyl-17-hydroxyestra-4, 9-dien-3-one STS 557 Endometrion Dienogest, Steroidal progesterone Dienogestrel //BP Dienogest (steroid) Visanne 2-((8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile [3H]-Dienogest Dienogest,Dienogestrel ,Dienogestril 3-(4-methoxyphenyl)-2-sulfanylidene-5,6,7,8-tetrahydro-1H-benzothiolo[2,3-d]pyrimidin-4-one STS557 Dinagest Dienogest, 10 mM in DMSO 17a-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile Dienogestril 17a-Cyanomethyl-17b-hydroxy-estra-4,9(10)-dien-3-one UNII-46M3EV8HHE STS 557;STS557;STS-557 Dienogest CRS 17a-Cyanomethyl-17-hydroxyestra-4,9-dien-3-one Dienogestrel 17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile 4, 9-ESTRADIENE-17α-CYANOMETHYL-17β-OL-3-ONE MJR-35 Dienogest for system suitability (Y0001782) Dienogest Impurity 17a-CyanoMethyl-17b-hydroxyestra-4, 9-dien-3-one ienoges BAY 8 (17α)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile (17a)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile (17R)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile Dinogest Dienogest (STS-557) BAY8 [14C]-Dienogest Contractive (oral) 19-Norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17α) Ene, with Dienogest for system suitability CRS 17a-CyanoMethyl-17b-hydroxyestra-4,9-dien-3-one 13C,2H3,15N]-Dienogest D6-Dienogest 17α-Cyanomethyl-17β-hydroxyestra-4,9-dien-3-one 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile Dienogestrel Impurity Dinogestrel Dinogestrin

描述	Dienogest(STS-557)是孕酮受体激动剂,有口服的子宫内膜活性,可作用于子宫内膜异位。
相关类别	信号通路 >> 自噬 >> 自噬信号通路 >> 其他 >> 孕激素受体研究领域 >> 内分泌
参考文献	[1]. Oettel M, et al. Effect of ethinyl estradiol-dienogest combination on serum androgen concentrations. Zentralbl Gynakol. 1997;119(12):597-606. [2]. Meena R, et al. Extended intervention time and evaluation of sperm suppression by dienogest plus testosterone undecanoate in male rat. Contraception. 2012 Jan;85(1):113-21.

密度	1.2±0.1 g/cm3
沸点	549.0±50.0 °C at 760 mmHg
熔点	210-214ºC
分子式	C₂₀H₂₅NO₂
分子量	311.418
闪点	285.8±30.1 °C
精确质量	311.188538
PSA	61.09000
LogP	1.96
外观性状	淡黄色固体
蒸汽压	0.0±3.3 mmHg at 25°C
折射率	1.589
储存条件	-20°C Freezer
水溶解性	水溶性：不溶；微溶：甲醇,丙酮；极微溶：乙醇

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC8899500

CHEMICAL NAME :: 19-Norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17-alpha)-

CAS REGISTRY NUMBER :: 65928-58-7

LAST UPDATED :: 199503

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C20-H25-N-O2

MOLECULAR WEIGHT :: 311.46

WISWESSER LINE NOTATION :: L E5 B666 OV BU MUTJ E1 FQ F1CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 300 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 461 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 25 mg/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 84 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 42 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 13-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 ug/kg

SEX/DURATION :: female 3-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 700 mg/kg

SEX/DURATION :: male 35 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 80 ug/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 ug/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 84 mg/kg

SEX/DURATION :: male 7 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 80 mg/kg

SEX/DURATION :: male 56 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 ug/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13500 ug/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 ug/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg/35D

REFERENCE :: ENDKAC Endokrinologie. (Leipzig, Ger. Dem. Rep.) V.1-80, 1928-82. For publisher information, see EXCEDS. Volume(issue)/page/year: 76,13,1980

符号	GHS08
信号词	Warning
危害声明	H361
警示性声明	P280
危害码 (欧洲)	Xn
危险品运输编码	NONH for all modes of transport

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