1031336-60-3

• 常用中文名：ABT-046
• 常用英文名：ABT-046
• CAS号：1031336-60-3
• 分子式：C₂₀H₂₂N₄O₂
• 分子量：350.41400
• 相关类别： 信号通路 代谢酶/蛋白酶 酰基转移酶
• 发布时间：2016-10-11 17:38:32
• 更新时间：2026-07-04 14:07:20
• ABT-046是高活性、口服生物相容性的二酰基甘油酰基转移酶1(DGAT-1)抑制剂,IC50为8 nM。

名称

• 中文名: ABT-046
• 英文名: 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid
• 中文别名: 反式-4-[4-(7-氨基吡唑并[1,5-A]嘧啶-6-基)苯基]环己烷乙酸
• 英文别名: DGAT-1 INHIBITOR; ABT 046;ABT046; trans-4-[4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexaneacetic acid; CS-1213; ABT 046; ABT-046||ABT 046|ABT046; 2-((1R,4R)-4-(4-(7-AMINOPYRAZOLO[1,5-A]PYRIMIDIN-6-YL)PHENYL)CYCLOHEXYL)ACETIC ACID; 2-(trans-4-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)cyclohexyl)acetic acid; Cyclohexaneacetic acid, 4-[4-(7-aMinopyrazolo[1,5-a]pyriMidin-6-yl)phenyl]-, trans; trans-{4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl}acetic acid; ABT 046,ABT046

物化性质

• 分子式: C₂₀H₂₂N₄O₂
• 分子量: 350.41400
• 精确质量: 350.17400
• PSA: 93.51000
• LogP: 4.30820
• 储存条件: 2-8℃

生物活性

• 描述: ABT-046是高活性、口服生物相容性的二酰基甘油酰基转移酶1(DGAT-1)抑制剂,IC50为8 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 酰基转移酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Yeh VS, et al. Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of Acyl-CoA: Diacylglycerol acyltransferase 1. J Med Chem. 2012 Feb 23;55(4):1751-1757.

合成路线

1031336-68-1 ~% 1031336-60-3

文献：Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757

1031336-85-2 ~% 1031336-60-3

文献：Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757

4894-75-1 ~% 1031336-60-3

文献：Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757

115880-04-1 ~% 1031336-60-3

文献：Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757

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1031336-68-1 1031336-85-2 4894-75-1 115880-04-1
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