ABT-046

Modify Date: 2024-01-14 11:10:19

ABT-046 Structure
ABT-046 structure
 Common Name ABT-046
CAS Number 1031336-60-3 Molecular Weight 350.41400
Density N/A Boiling Point N/A
Molecular Formula C20H22N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ABT-046


ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).IC50 value: 8 nM [1]Target: DGAT-1Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046.

 Names

Name 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid
Synonym More Synonyms

 ABT-046 Biological Activity

Description ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM).IC50 value: 8 nM [1]Target: DGAT-1Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046.
Related Catalog
References

[1]. Yeh VS, et al. Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of Acyl-CoA: Diacylglycerol acyltransferase 1. J Med Chem. 2012 Feb 23;55(4):1751-1757.

 Chemical & Physical Properties

Molecular Formula C20H22N4O2
Molecular Weight 350.41400
Exact Mass 350.17400
PSA 93.51000
LogP 4.30820
Storage condition 2-8℃

 Synthetic Route

Cyclohexaneacetic acid, 4-[4-(chlorocarbonyl)phenyl]-, ethyl ester, trans- structure

Cyclohexaneacet...

CAS#:1031336-68-1

~%

ABT-046 Structure

ABT-046

CAS#:1031336-60-3
Literature: Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757
Cyclohexaneacetic acid, 4-[4-(cyanomethyl)phenyl]-, ethyl ester, trans- structure

Cyclohexaneacet...

CAS#:1031336-85-2

~%

ABT-046 Structure

ABT-046

CAS#:1031336-60-3
Literature: Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757
4-Phenylcyclohexanone structure

4-Phenylcyclohe...

CAS#:4894-75-1

~%

ABT-046 Structure

ABT-046

CAS#:1031336-60-3
Literature: Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757
ethyl 2-(4-phenylcyclohexylidene)acetate structure

ethyl 2-(4-phen...

CAS#:115880-04-1

~%

ABT-046 Structure

ABT-046

CAS#:1031336-60-3
Literature: Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757

 Synonyms

CS-1213
ABT 046
ABT-046||ABT 046|ABT046
trans-{4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl}acetic acid
ABT-046
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  • Purity: 98.0%
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Chemsrc provides ABT-046(CAS#:1031336-60-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ABT-046 are included as well.>> amp version: ABT-046

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