189279-58-1

• 常用中文名：德拉沙星
• 常用英文名：Delafloxacin
• CAS号：189279-58-1
• 分子式：C₁₈H₁₂ClF₃N₄O₄
• 分子量：440.760
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-10-17 17:55:57
• 更新时间：2024-01-02 19:06:59
• Delafloxacin (RX-3341, ABT-492)是氟喹诺酮类抗生素。

名称

• 中文名: 德拉沙星
• 英文名: 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxoquinoline-3-carboxylic acid
• 英文别名: 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-7-(3-hydroxy-1-azetidinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; T66 BN EVJ DVQ HF JG B- BT6NJ CF EF FZ& I- AT4NTJ CQ; 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid; 1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; Delafloxacin; 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-; WQ-3034; Delafloxacin (USAN); ABT-492; 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; RX-3341; Delafloxacin

物化性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 698.5±55.0 °C at 760 mmHg
• 分子式: C₁₈H₁₂ClF₃N₄O₄
• 分子量: 440.760
• 闪点: 376.2±31.5 °C
• 精确质量: 440.049927
• PSA: 122.41000
• LogP: 0.81
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.717
• 储存条件: -20°C

生物活性

• 描述: Delafloxacin (RX-3341, ABT-492)是氟喹诺酮类抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Gunderson SM, Hayes RA, Quinn JP, In vitro pharmacodynamic activities of ABT-492, a novel quinolone, compared to those of levofloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Antimicrob Agents Chemother. 2004 Jan;48(1):203-8.

  [2]. Goldstein EJ, Citron DM, Merriam CV, In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis. Antimicrob Agents Chemother. 2003 Sep;47(9):3008-11.

  [3]. Nilius AM, Shen LL, Hensey-Rudloff D, In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. Antimicrob Agents Chemother. 2003 Oct;47(10):3260-9.

安全

• 危害码 (欧洲): Xi

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