362-74-3

• 常用中文名：二丁酰环磷腺苷钙
• 常用英文名：Bucladesine
• CAS号：362-74-3
• 分子式：C₁₈H₂₄N₅O₈P
• 分子量：469.386
• 相关类别： 生物化工 核苷类药物 核苷中间体
• 发布时间：2018-08-26 17:00:13
• 更新时间：2024-01-03 16:33:55
• Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. Bucladesine is a phosphodiesterase inhibitor. Bucladesine is a cell permeable cAMP analog. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions. cAMP is only able to elicit minimal responses in these situations. The neurite outgrowth instigated by bucladesine in cell cultures has been shown to be enhanced by nardosinone.

名称

• 中文名: 二丁酰环磷腺苷
• 英文名: Bucladesine
• 中文别名: 二丁酰环磷腺甙; 布拉地新
• 英文别名: dibutyryl cAMP; Bt2 cyclic AMP; (4aR,6R,7R,7aR)-6-[6-(butanoylamino)-9H-purin-9-yl]-2-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butanoate; 3',5'-Cyclic AMP dibutyrate; n-6,o-2'-dibutyryl adenosine cyclic 3':5'-monophosphate; Cyclic AMP dibutyrate; N-(9-b-D-Ribofuranosyl-9H-purin-6-yl)butyramide Cyclic 3',5'-(Hydrogen Phosphate) 2'-Butyrate; N6,2'-O-Dibutyryl cAMP; N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate; Butanoic acid, (4aR,6R,7R,7aR)-tetrahydro-2-hydroxy-2-oxido-6-[6-[(1-oxobutyl)amino]-9H-purin-9-yl]-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-7-yl ester; N6,2'-O-dibutyryl-cAMP; Bucladesine; (4aR,6R,7R,7aR)-6-[6-(Butyrylamino)-9H-purin-9-yl]-2-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butyrate; Dibutyryl cyclic 3',5'-AMP; dibutyryl cyclic AMP; CalciuM Dibutyacyladenosine; N,O-dibutyryl cyclic AMP; N-(9-beta-D-Ribofuranosyl-9H-furin-6-yl)-butyramidecyclic3',5'-(hydrogenphosphate)2'-butyrate; N-(1-Oxobutyl)adenosine Cyclic 3',5'-(Hydrogen Phosphate) 2'-Butanoate; Dibutyryl-cAMP; Dibutyryl 3',5'-Cyclic AMP

物化性质

• 密度: 1.7±0.1 g/cm3
• 熔点: 203 - 205 °C
• 分子式: C₁₈H₂₄N₅O₈P
• 分子量: 469.386
• 精确质量: 469.136261
• PSA: 173.80000
• LogP: 1.76300
• 折射率: 1.717
• 储存条件: 室温

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ES5055000 CHEMICAL NAME : Butyramide, N-(9-beta-D-ribofuranosyl-9H-furin-6-yl)-, cyclic 3',5'-(hydrogen phosphate) 2'- butyrate CAS REGISTRY NUMBER : 362-74-3 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C18-H24-N5-O8-P MOLECULAR WEIGHT : 469.44 WISWESSER LINE NOTATION : T56 BO FOPOTJ DOV3 GQ GO C- DT56 BN DN FN HNJ IMV3 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 50 umol/L REFERENCE : JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 66,313,1976