72141-57-2

• 常用中文名：洛硫嗪
• 常用英文名：Losulazine
• CAS号：72141-57-2
• 分子式：C₂₇H₂₂F₄N₄O₃S
• 分子量：558.54700
• 发布时间：2018-09-18 16:06:50
• 更新时间：2024-01-06 07:03:29

名称

• 中文名: 洛硫嗪
• 英文名: [4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone
• 英文别名: Losulazina; Losulazine; Losulazinum

物化性质

• 密度: 1.454g/cm3
• 沸点: 695.7ºC at 760 mmHg
• 分子式: C₂₇H₂₂F₄N₄O₃S
• 分子量: 558.54700
• 闪点: 374.5ºC
• 精确质量: 558.13500
• PSA: 90.99000
• LogP: 6.31260
• 折射率: 1.638

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TM0829800 CHEMICAL NAME : Piperazine, 1-((4-fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethy l)-4-quinolinyl)amino) benzoyl)- CAS REGISTRY NUMBER : 72141-57-2 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C27-H22-F4-N4-O3-S MOLECULAR WEIGHT : 558.59 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,133,1986 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 168 mg/kg SEX/DURATION : lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 33,36C,1986

合成路线

349-88-2 72141-43-6 ~90% 72141-57-2

文献：McCall, John M.; TenBrink, R. E.; Kamdar, Bharat V.; Skaletzky, Louis L.; Perricone, Salvatore C.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 133 - 137

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