Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Losulazine
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Purity: 98.0%
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72141-57-2

72141-57-2 structure

72141-57-2 structure

Name: Losulazine
Chemical Name: [4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone
CAS Number: 72141-57-2
Molecular Formula: C₂₇H₂₂F₄N₄O₃S
Molecular Weight: 558.54700
Create Date: 2018-09-18 16:06:50
Modify Date: 2024-01-06 07:03:29

Name	[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone
Synonyms	Losulazina Losulazine Losulazinum

Density	1.454g/cm3
Boiling Point	695.7ºC at 760 mmHg
Molecular Formula	C₂₇H₂₂F₄N₄O₃S
Molecular Weight	558.54700
Flash Point	374.5ºC
Exact Mass	558.13500
PSA	90.99000
LogP	6.31260
Index of Refraction	1.638

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM0829800

CHEMICAL NAME :: Piperazine, 1-((4-fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethy l)-4-quinolinyl)amino) benzoyl)-

CAS REGISTRY NUMBER :: 72141-57-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H22-F4-N4-O3-S

MOLECULAR WEIGHT :: 558.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,133,1986 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 168 mg/kg

SEX/DURATION :: lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 33,36C,1986

349-88-2 structure

349-88-2

72141-43-6 structure

72141-43-6

~90%

72141-57-2 structure

72141-57-2

Literature: McCall, John M.; TenBrink, R. E.; Kamdar, Bharat V.; Skaletzky, Louis L.; Perricone, Salvatore C.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 133 - 137

Precursor 2
349-88-2 72141-43-6
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