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53251-94-8生产厂家

53251-94-8价格

53251-94-8

53251-94-8结构式
53251-94-8结构式
  • 常用中文名:匹维溴铵
  • 常用英文名:L-Pinaverium bromide
  • CAS号:53251-94-8
  • 分子式:C26H41Br2NO4
  • 分子量:591.416
  • 相关类别: 原料药 Anesthetic Agents 骨骼肌松弛药
  • 发布时间:2018-08-12 18:32:31
  • 更新时间:2024-01-04 12:24:34
  • Pinaverium bromide 是一种对胃肠道具有选择性的L型 钙通道 阻滞剂,能有效缓解疼痛、腹泻和肠道不适,对肠易激综合征 (IBS) 患者有良好的治疗效果,且无不良反应。

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中文名 匹维溴胺
英文名 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium,bromide
中文别名 4-[(2-溴-4,5-二甲氧基苯基)甲基]-4-[2-[2-(7,7-二甲基-2-双环[3.1.1]庚烷基)乙氧基]乙基]吗啉-4-翁溴化物
匹维溴铵
英文别名 4-(6-Bromoveratryl)-4-[2-[2-(6,6-dimethyl-2-norpinyl)ethoxy]ethyl]morpholinium Bromide
LAT 1717
Dicetel
EINECS 258-450-0
Pinaverium bromide
UNII-7SCF54H12J
Morpholinium, 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, bromide (1:1)
4-(2-Bromo-4,5-dimethoxybenzyl)-4-{2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl}morpholin-4-ium bromide
4-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]morpholinium Bromide
描述 Pinaverium bromide 是一种对胃肠道具有选择性的L型 钙通道 阻滞剂,能有效缓解疼痛、腹泻和肠道不适,对肠易激综合征 (IBS) 患者有良好的治疗效果,且无不良反应。
相关类别
靶点

Calcium channel[1].

参考文献

[1]. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.

熔点 159-164ºC
分子式 C26H41Br2NO4
分子量 591.416
精确质量 589.140198
PSA 36.92000
LogP 2.25510
外观性状 固体;White to Light yellow powder to crystal
储存条件 -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QF2810000
CHEMICAL NAME :
Morpholinium, 4-(2-bromo-4,5-dimethoxy)benzyl-4-(2-(2-(6,6-dimethyl -2-norpinyl)ethoxy) ethyl)-, bromide
CAS REGISTRY NUMBER :
53251-94-8
LAST UPDATED :
199109
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C26-H41-Br-N-O4.Br
MOLECULAR WEIGHT :
591.50
WISWESSER LINE NOTATION :
L46 ATJ A1 A1 E2O2- AT6K DOTJ A1R BE DO1 EO1 &E &24/47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,182,1974

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