69866-21-3

• 常用中文名：Rachelmycin
• 常用英文名：Rachelmycin
• CAS号：69866-21-3
• 分子式：C₃₇H₃₃N₇O₈
• 分子量：703.70000
• 相关类别： 信号通路 细胞周期/DNA损伤 DNA/RNA合成
• 发布时间：2017-12-05 21:46:18
• 更新时间：2024-01-13 11:12:38
• Rachelmycin (CC-1065; NSC 298223) 是一种从 Streptomyces zelensis 中分离得到有效的天然抗生素 (antibiotic)。Rachelmycin 在 B 型 DNA 的小沟中非共价和共价结合 (N-3 腺嘌呤加合物)。Rachelmycin 具有极强的抗肿瘤活性。

名称

• 英文名: Benzo[1,2-b_4,3-b']dipyrrole-3(2H)-carboxamide, 7-[[1,6-dihydro-4-hydroxy-5-methoxy-7-[(4,5,8,8a-tetrahydro-7-methyl-4-oxocyclopropa[c]pyrrolo[3,2-e]indol-2(1H)-yl)carbonyl]benzo[1,2-b_4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1,6-dihydro-4-hydroxy-5-methoxy
• 英文别名: (+)-(3bR,4aS)-CC-1065; (+)-CC-1065; Rachelmycin

物化性质

• 密度: 1.75g/cm3
• 分子式: C₃₇H₃₃N₇O₈
• 分子量: 703.70000
• 精确质量: 703.23900
• PSA: 210.31000
• LogP: 4.62030
• 折射率: 1.878
• 储存条件: 库房通风低温干燥,与食品原料分开存放

生物活性

• 描述: Rachelmycin (CC-1065; NSC 298223) 是一种从 Streptomyces zelensis 中分离得到有效的天然抗生素 (antibiotic)。Rachelmycin 在 B 型 DNA 的小沟中非共价和共价结合 (N-3 腺嘌呤加合物)。Rachelmycin 具有极强的抗肿瘤活性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
• 体内研究: 在对非肿瘤性BDF1小鼠的实验中,发生延迟死亡的最小剂量为拉赫霉素(CC-1065；NSC 298223；12.5 mg/kg)[1]。
• 参考文献:

  [1]. W C Krueger, et al. Calf Thymus DNA binding/bonding Properties of CC-1065 and Analogs as Related to Their Biological Activities and Toxicities. Chem Biol Interact. 1992 Mar;82(1):31-46.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DF4936700 CAS REGISTRY NUMBER : 69866-21-3 LAST UPDATED : 199806 DATA ITEMS CITED : 17 MOLECULAR FORMULA : C37-H33-N7-O8 MOLECULAR WEIGHT : 703.77 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >8 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >8800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6900 ng/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9 ug/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1 ug/kg TOXIC EFFECTS : Liver - fatty liver degeneration TYPE OF TEST : Micronucleus test MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 7400 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,999,1982 *** REVIEWS *** TOXICOLOGY REVIEW JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 39,319,1986

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