21637-25-2

• 常用中文名：异槲皮苷
• 常用英文名：Isoquercitrin
• CAS号：21637-25-2
• 分子式：C₂₁H₂₀O₁₂
• 分子量：464.376
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-07-07 20:19:31
• 更新时间：2026-07-01 10:29:08
• Isoquercitrin 是一种有效的抗氧化剂和嗜酸性炎症抑制剂。

名称

• 中文名: 异槲皮苷
• 英文名: quercetin 3-O-β-D-glucofuranoside
• 中文别名: 异槲皮甙,异栎素,槲皮素-3-葡萄糖甙; 3-(((2S,3R,4R,5R)-5-((R)-1,2-二羟基乙基)-3,4-二羟基四氢呋喃-2-基)氧基)-2-(3,4-二羟基苯基)-5,7-二羟基-4H-苯并吡喃-4-酮; 罗布麻甲素; 槲皮素-吡喃葡糖苷; 槲皮素-3-O-葡萄糖苷; ISOQUERCITRIN 异槲皮苷; 异槲皮甙; 槲皮素-3-Β-D-葡萄糖苷; 槲皮素-3-O-葡萄糖苷,异槲皮苷; 槲皮素-3-贝他-D-葡萄糖苷/异槲皮甙; 异槲皮苷 标准品; 槲皮素-3-O-葡萄糖苷 / 异槲皮苷(异槲皮素); 槲皮素-3-葡萄糖甙; 异槲皮苷, (HPLC); ISOQUERCITRIN 异槲皮苷 标准品; 槲皮素-3-氧葡萄糖甙; 槲皮素-3-呋喃葡糖苷; 槲皮素-3-O-Β-D-吡喃葡萄糖苷; 异槲皮苷/Quercetin 3-β-D-glucoside; 异栎素; (3-槲皮素)-β-D-葡萄糖苷; Isoquercitrin 异槲皮苷 标准品 Isoquercitrin; (3-槲皮素)-Β-D-葡萄糖苷; ISOQUERCETIN|||ISOQUERCITROSIDE|||槲皮素-3-氧葡萄糖甙; 异槲皮苷(标准品)
• 英文别名: Isotrifoliin; QUERCETIN-3-O-BETA-GLUCOPYRANOSIDE; 3,3’,4’,5,7-pentahydroxy-flavon3-beta-d-glucofuranoside; ISOQUERCITRIN (DISCONTINUED)(SH); Rutoside Impurity A; 3-(((2S,3R,4R,5R)-5-((R)-1,2-Dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; soquercitrin; trifoliin; Isoquercitrin (Isoquercitroside; Isoquercitrin / quercetin glycoside; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy; Quercetin 3-b-D-glucoside; QUERCETIN-3-O-BETA-D-GLUCOPYRANOSIDE; quercetin 3-O-β-D-glucopyranoside; Quercetin 3β-O-glucoside; Quercetin 3; quercetin3-O-β-D-glucofuranoside; ISOTRIFOLIN; Quercetin 3-O-glucofuranoside; QUERCETIN-3-GLUCOSIDE; ISOQUERCITRIN b; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucopyranoside; 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy); 3-(β-D-Glucofuranosyloxy)-5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one; quercetin-3-glucoside; 3-O-β-D-Glucopyranosylquercetin; Isoquercitroside; Quercetin-3-O-β-glucopyranoside; Cocaflavin; ISOQUERCITROSIDE; Isoquercetrin; Quercetin 3-O-glucoside; QUERCETIN 3-O-GLUCOPYRANOSIDE; 2-(3,4-Dihidroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; Quercetin 3-β-D-glucoside ,>=; quercetin 3-O-β-D-glucoside; Quercitin-3-beta-D-glucofuranoside; Hirsutrin; isotrifoliin; 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihyd; 3,3',4',5,7-Pentahydroxyflavone 3-b-D-glucofuranoside; Quercetin-3-β-glucopyranoside; Quercetin 3-β-O-glucoside; 2-(3,4-Dihydroxyphenyl)-3-(b-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; 3,3',4',5,7-Pentahydroxyflavone 3-β-glucoside; ningenin-7-O-β-D-glucoside; Quercetin 3-glucofranoside; Quercetin 3-β-D-glucoside, (HPLC); Quercetin 3-O-β-glucoside; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucofuranoside; ISOQUERCITRIN hplc; ISOQUERCETIN; ISOQUERCITRIN; Quercetin 3-β-glucoside; 4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-3-(beta-d-glucofuranosyloxy)-5; 2,4-Dichlorobenzyl Alcohol Impurity 8 (3,4-Dichlorobenzyl Mercaptan); 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; Quercetin 3-Oxyglucoside; Isopseudopsoralen; isopseudopsoralene; QUERCETIN-3-BETA-D-GLUCOSIDE; 3,4,5',7'-TETRAHYDROXYFLAVONE-3'-GLUCOSIDE; Isoquercitroside CRS; Quercetin 3-β-D-glucoside; 2-(3,4-Hihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; 2-(3,4-dihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; Quercetin glucoside; Quercitin-3'-O- glucofuranoside; Quercetin-3-O-β-D-glucoside; 3,3',4',5,7-PENTAHYDROXYFLAVONE-3-BETA-GLUCOSIDE; isopseudosporalen; 7-dihydroxy; Quercetin 3-D-glucoside; QUERCETIN-3-O-B-GLUCOPYRANOSIDE; isoquercetin; 3,3’,4’,5,7-pentahydroxyflavone3-beta-d-glucofuranoside; Isoquercitrin (Synonyms: Isoquercitroside; QUERCETIN-3-O-B-D-GLUCOFURANOSIDE; quercetin 3-O-beta-D-glucofuranoside; 3-[[(2S,3R,4R,5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2-oxolanyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyran-4-one; Quercetin-3-O-glucoside; Quercetin 3-β-D-glucoside,3,3′,4′,5,7-Pentahydroxyflavone 3-β-glucoside, Isoquercitrin; QUERCETIN-3-O-GLUCOSIDE; Quercetin 3-β-D-gluc; C05623; Quercetin 3-O-glucopyranoside

物化性质

• 密度: 1.9±0.1 g/cm3
• 沸点: 872.6±65.0 °C at 760 mmHg
• 熔点: 225-227°
• 分子式: C₂₁H₂₀O₁₂
• 分子量: 464.376
• 闪点: 307.5±27.8 °C
• 精确质量: 464.095490
• PSA: 210.51000
• LogP: 1.75
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.803
• 储存条件: −20°C

生物活性

• 描述: Isoquercitrin 是一种有效的抗氧化剂和嗜酸性炎症抑制剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 黄酮类化合物
  研究领域 >> 炎症/免疫
• 体外研究: 异槲皮苷广泛存在于植物中.7种化合物中的10μM异槲皮苷部分但显着地减弱了H2O2对RGC-5细胞的负面影响,因为H2O2存在时细胞的存活率从大约63％增加到83％和90％分别为10和50μM时的％。实际上,50μM等槲皮苷作为神经保护剂比相同浓度的EGCG更有效[1]。
• 体内研究: 在接受异槲皮苷或槲皮素的动物中,BALF,血液和肺实质中的嗜酸性粒细胞计数较低。血液中的中性粒细胞计数和肺匀浆中的IL-5水平仅在Isoquercitrin处理的小鼠中较低。没有观察到单核细胞数量的改变[2]。
• 动物实验: 免疫小鼠[2] BALB / c小鼠（卵清蛋白/氢氧化铝，sc），然后进行两次鼻内卵清蛋白攻击。从第一次免疫后第18天到第22天，小鼠每天接受异槲皮苷（15mg / kg）或槲皮素（10mg / kg）的强饲。施用地塞米松（1mg / kg，sc）作为阳性对照。在最后一次卵清蛋白激发后24小时，在支气管肺泡灌洗液（BALF），血液和肺实质中分析白细胞。白细胞介素-5（IL-5）在BALF和肺匀浆中进行分析[2]。
• 参考文献:

  [1]. Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21.

  [2]. Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LK8960000 CHEMICAL NAME : Flavone, 3,3',4',5,7-pentahydroxy-, 3-beta-D-glucofuranoside CAS REGISTRY NUMBER : 21637-25-2 LAST UPDATED : 199410 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C21-H20-O12 MOLECULAR WEIGHT : 464.41 WISWESSER LINE NOTATION : T66 BO EVJ CR CQ DQ& DO- BT5OTJ CQ DQ EYQ1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 40 ug/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

安全

• 安全声明 (欧洲): 24/25
• 危险品运输编码: UN 2811
• WGK德国: 3
• RTECS号: LK8960000

上下游产品

上游产品  0
下游产品  2
50-99-7 117-39-5