Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isoquercitrin
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DC Chemicals Limited
China
Product Name: Isoquercitrin (Isoquercitroside; Isoquercetin)
Price: $850.0/100mg $1700.0/250mg $3400.0/1g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isoquercitrin
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Zhejiang Hangyu API Co., Ltd
China
Product Name: ISOQUERCITRIN
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Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: ISOQUERCITRIN
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Purity: 99.0%
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Contact: Anson

21637-25-2

21637-25-2 structure

21637-25-2 structure

Name: Isoquercitrin
Chemical Name: quercetin 3-O-β-D-glucofuranoside
CAS Number: 21637-25-2
Molecular Formula: C₂₁H₂₀O₁₂
Molecular Weight: 464.376
Catalog: Biochemical Plant extracts
Create Date: 2018-07-07 20:19:31
Modify Date: 2024-01-02 18:34:25
Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.

Name	quercetin 3-O-β-D-glucofuranoside
Synonyms	Quercetin 3-O-β-glucoside trifoliin 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucofuranoside quercetin 3-O-β-D-glucopyranoside Quercetin 3β-O-glucoside 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy- 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxy-phenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy- Quercetin 3-β-glucoside Quercetin 3-O-glucofuranoside 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucopyranoside Isopseudopsoralen isopseudopsoralene Quercetin 3-β-D-glucoside quercetin-3-glucoside 3-O-β-D-Glucopyranosylquercetin Quercetin glucoside Isoquercitroside Quercetin-3-O-β-D-glucoside isopseudosporalen Quercetin-3-O-β-glucopyranoside Isoquercetrin Quercetin 3-O-glucoside Quercetin 3-D-glucoside Isoquercitrin isoquercetin quercetin 3-O-β-D-glucoside Hirsutrin isotrifoliin 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucopyranosyloxy)-5,7-dihydroxy- 3,3',4',5,7-Pentahydroxyflavone 3-b-D-glucofuranoside Quercetin-3-β-glucopyranoside quercetin 3-O-beta-D-glucofuranoside Quercetin-3-O-glucoside Quercetin 3-β-O-glucoside 2-(3,4-Dihydroxyphenyl)-3-(b-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one Quercetin 3-O-glucopyranoside

Description	Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology
In Vitro	Isoquercitrin occurs widely in plants.10 μM of Isoquercitrin of the seven compounds partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG[1].
In Vivo	In animals receiving Isoquercitrin or quercetin, eosinophil counts are lower in the BALF, blood and lung parenchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate are lower only in Isoquercitrin-treated mice. No alterations in mononuclear cell numbers were observed[2].
Animal Admin	Mice[2] BALB/c mice are immunized (ovalbumin/aluminum hydroxide, s.c.), followed by two intranasal ovalbumin challenges. From day 18 to day 22 after the first immunization, the mice receive daily gavages of Isoquercitrin (15 mg/kg) or quercetin (10 mg/kg). Dexamethasone (1 mg/kg, s. c.) is administered as a positive control. Leucocytes are analyzed in bronchoalveolar lavage fluid (BALF), blood and pulmonary parenchyma at 24 h after the last ovalbumin challenge. Interleukin-5 (IL-5) is analyzed in BALF and lung homogenates[2].
References	[1]. Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21. [2]. Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8.

Density	1.9±0.1 g/cm3
Boiling Point	872.6±65.0 °C at 760 mmHg
Melting Point	225-227°
Molecular Formula	C₂₁H₂₀O₁₂
Molecular Weight	464.376
Flash Point	307.5±27.8 °C
Exact Mass	464.095490
PSA	210.51000
LogP	1.75
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.803
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8960000

CHEMICAL NAME :: Flavone, 3,3',4',5,7-pentahydroxy-, 3-beta-D-glucofuranoside

CAS REGISTRY NUMBER :: 21637-25-2

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H20-O12

MOLECULAR WEIGHT :: 464.41

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& DO- BT5OTJ CQ DQ EYQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 40 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

Safety Phrases	24/25
RIDADR	UN 2811
WGK Germany	3
RTECS	LK8960000

Precursor 0
DownStream 2
50-99-7 117-39-5