506-17-2

506-17-2结构式

常用中文名：十八烷酸
常用英文名：cis-Vaccenic acid
CAS号：506-17-2
分子式：C₁₈H₃₄O₂
分子量：282.461
相关类别：化学试剂有机试剂脂肪酸
发布时间：2018-05-25 08:00:00
更新时间：2025-08-21 11:39:41
顺式真空酸是从荚膜红假单胞菌中提取的抗病毒提取物,也是荚膜红假单胞菌的主要活性成分[1],是一种潜在的胎儿血红蛋白诱导剂[2]。

化源商城直购

中文名	十八烷酸
英文名	cis-vaccenic acid
中文别名	顺式十八碳烯酸顺-11-十八烯酸
英文别名	(Z)-11-octadecenoic acid cis-Vaccenic acid 11-Octadecenoic acid, (Z)- 11-cis-Octadecenoic acid cis-11-Octadecenoic acid MFCD00063187 11(Z)-Octadecenoic acid 11-Octadecenoic acid, (11Z)- (11Z)-11-Octadecenoic acid asclepic acid Vaccenic acid 11Z-Octadecenoic acid (11Z)-Octadec-11-enoic acid (Z)-vaccenic acid cis-11-Vaccenic acid

描述	顺式真空酸是从荚膜红假单胞菌中提取的抗病毒提取物,也是荚膜红假单胞菌的主要活性成分[1],是一种潜在的胎儿血红蛋白诱导剂[2]。
相关类别	研究领域 >> 癌症信号通路 >> 其他 >> 其他
体外研究	顺式真空酸(CVA)(50μM、70μM和100μM)诱导K562、JK1和转基因小鼠红系祖细胞分化并上调γ-珠蛋白合成[2]。顺式真空酸(50μM)也增加了联苯胺阳性JK-1细胞的百分比[2]。细胞分化试验[2]细胞系：K562细胞浓度：50μM,70μM和100μM孵育时间：48和120小时结果：诱导分化在K562细胞中呈浓度依赖性,50μM CVA是最有效的浓度,超过20%的K562细胞在与CVA孵育48小时后联苯胺染色呈阳性。
参考文献	[1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7. [2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18.

密度	0.9±0.1 g/cm3
沸点	398.2±11.0 °C at 760 mmHg
熔点	14-15ºC(lit.)
分子式	C₁₈H₃₄O₂
分子量	282.461
闪点	295.0±14.4 °C
精确质量	282.255890
PSA	37.30000
LogP	7.70
外观性状	oil
蒸汽压	0.0±2.0 mmHg at 25°C
折射率	1.467
储存条件	-20°C密封保存，放置在通风，干燥的环境中
稳定性	按规格使用和贮存，不会发生分解，避免与氧化物接触
分子结构	1、摩尔折射率：87.06 2、摩尔体积（cm³/mol）：313.8 3、等张比容（90.2K）：757.2 4、表面张力（dyne/cm）：33.8 5、极化率（10^-24cm³）：34.51
计算化学	1、疏水参数计算参考值（XlogP）：6.5 2、氢键供体数量：1 3、氢键受体数量：2 4、可旋转化学键数量：15 5、互变异构体数量： 6、拓扑分子极性表面积（TPSA）：37.3 7、重原子数量：20 8、表面电荷：0 9、复杂度：234 10、同位素原子数量：0 11、确定原子立构中心数量：0 12、不确定原子立构中心数量：0 13、确定化学键立构中心数量：1 14、不确定化学键立构中心数量：0 15、共价键单元数量：1
更多	1. 性状：未确定 2. 相对密度（25℃，4℃）：0.8390⁸⁰ 3. 相对密度（20℃，4℃）：0.8469⁷⁰ 4. 熔点（ºC）：69.6 5. 沸点（ºC,常压）：376 6. 常温折射率（n²⁰）：1.4337⁷⁰ 7. 折射率：1.459 8. 闪点（ºC）：230 9.常温折射率（n²⁵）：1.4299⁸⁰ 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：未确定

Section 1. Chemical Product and Company Identification
cis-Vaccenic Acid, synthetic
Common Name/
Trade Name
cis-Vaccenic Acid, synthetic

Section 4. First Aid Measures

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
Eye Contact
15 minutes. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Skin Contact
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Not available.
Serious Inhalation
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Not available.
Serious Ingestion

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
CLOSED CUP: 230°C (446°F).
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2).
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat.
Various Substances
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards in
Risks of explosion of the product in presence of static discharge: Not available.
Presence of Various
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Not available.
Special Remarks on
Fire Hazards
Not available.
Special Remarks on
Explosion Hazards

Section 6. Accidental Release Measures
Absorb with an inert material and put the spilled material in an appropriate waste disposal.
Small Spill
Absorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning by
Large Spill
spreading water on the contaminated surface and allow to evacuate through the sanitary system.
cis-Vaccenic Acid, synthetic

Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
breathe gas/fumes/ vapor/spray. Keep away from incompatibles such as oxidizing agents, alkalis.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 0°C (32°F).
Storage
Freeze. Sensitive to light. Store in light-resistant containers.

Section 8. Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
Engineering Controls
respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station
location.
Personal ProtectionSafety glasses. Lab coat. Gloves (impervious).
Personal Protection in Case Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
of a Large Spill
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Liquid.Not available.
Physical state andO dor
appearance
Not available.
Taste
282.47 g/mole
Molecular Weight
Not available.
Color
Not available.
pH (1% soln/water)
158°C (316.4°F) - 163 C. at 0.4 mm Hg
Boiling Point
14°C (57.2°F) -15 C.
Melting Point
Not available.
Critical Temperature
0.88 - 0.89 (Water = 1)
Specific Gravity
Not available.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
Not available.
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
Not available.
Dispersion Properties
Not available.
Solubility

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Conditions of Instability Excess heat, incompatible materials
Incompatibility with various Reactive with oxidizing agents, alkalis.
substances
Not available.
Corrosivity
cis-Vaccenic Acid, synthetic
Sensitive to light.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization

Section 11. Toxicological Information
Absorbed through skin. Eye contact. Ingestion.
Routes of Entry
LD50: Not available.
Toxicity to Animals
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Not available.
Special Remarks on
Toxicity to Animals
Not available.
Special Remarks on
Chronic Effects on Humans
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: Can cause mild to moderate skin irritation.
Eyes: Can cause mild eye irritation.
Inhalation: Inhalation of mist or vapor may cause respiratory tract irritation.
Ingestion: Expected to be a low hazard.

Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The product itself and its products of degradation are not toxic.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation

Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control
Waste Disposal
regulations.

Section 14. Transport Information
Not a DOT controlled material (United States).
DO T Cl assi fi cati on
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
cis-Vaccenic Acid, synthetic
DO T (Pi ctograms)

Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has found to
California
cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsEINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances.
Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL).
China: Not listed on National Inventory.
Japan: Listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Not listed on AICS.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
This product is not classified according Not applicable.
DSCL (EEC)
to the EU regulations.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
1
Specific hazard
Personal Protection
B
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG(Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves (impervious).
cis-Vaccenic Acid, synthetic
Lab coat.
Not applicable.

SECTION 16 - ADDITIONAL INFORMATION
N/A

生态学数据:

该物质对环境可能有危害，对水体应给予特别注意。

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	Xi
风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-36
危险品运输编码	NONH for all modes of transport
WGK德国	3
海关编码	2916190090

上游产品 9
19220-40-7 111-71-7 7530-96-3 111-25-1
16900-60-0 18202-10-3 2834-05-1 60-33-3
2536-38-1
下游产品 8
143288-76-0 88657-37-8 111-71-7 95548-26-8
693-72-1 6198-58-9 1852-04-6 53163-99-8

海关编码	2916190090
中文概述	2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

506-17-2	506-48-9
109-36-4	143-25-9
17437-24-0	55682-92-3
15242-96-3	27986-38-5
26856-11-1	45261-96-9
1909335-90-5	1909305-91-4
1909358-89-9	1909320-28-0
1909293-87-3	1909286-95-8
1955557-67-1	1909314-29-9
1909335-94-9	38228-13-6

506-17-2

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